Short answer: The Provera label gives 5 or 10 mg by mouth daily for 5 to 10 days for secondary amenorrhea, or starting on day 16 or 21 of the cycle for abnormal uterine bleeding. With daily conjugated estrogens 0.625 mg after menopause, it gives 5 or 10 mg daily for 12 to 14 straight days a month. Withdrawal bleeding usually follows within 3 to 7 days. The label has no missed-dose rule.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Provera is approved for: Provera is approved to treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance with no physical cause such as fibroids or uterine cancer, and to help prevent endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women with a uterus who take daily conjugated estrogens 0.625 mg tablets (Indications and Usage).
Source
PROVERA (medroxyprogesterone acetate tablets, USP), prescribing information and Patient Information. Pfizer (Pharmacia & Upjohn). DailyMed, version published June 30, 2026. DailyMed setid a586be28-96af-4fed-a13f-9b94fd4c7405
Provera is a tablet taken by mouth. It comes in 2.5 mg (orange), 5 mg (blue) and 10 mg (white) scored tablets (How Supplied).
The label says patients start at the lowest dose and that the lowest effective dose has not been determined. With estrogen, treatment is reviewed periodically, for example every 3 to 6 months, to see whether it is still needed (Dosage and Administration).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Use | Dose | When and how long | Notes on the label |
|---|---|---|---|
| Secondary amenorrhea | 5 or 10 mg daily | 5 to 10 days; may start at any time | 10 mg daily for 10 days for an estrogen-primed lining; withdrawal bleeding usually 3 to 7 days after stopping |
| Abnormal uterine bleeding from hormonal imbalance | 5 or 10 mg daily | 5 to 10 days, starting on the calculated 16th or 21st day of the cycle | 10 mg daily for 10 days from day 16 suggested for an estrogen-primed lining; withdrawal bleeding usually 3 to 7 days after stopping |
| Preventing endometrial hyperplasia with daily conjugated estrogens 0.625 mg | 5 or 10 mg daily | 12 to 14 consecutive days per month, beginning on day 1 or day 16 of the cycle | Start at the lowest dose |
A postmenopausal woman with a uterus who is prescribed estrogen also starts a progestin to reduce endometrial cancer risk. A woman without a uterus does not need a progestin.
Estrogen, alone or with a progestin, is used at the lowest effective dose for the shortest time consistent with treatment goals and risks.
People with a past history of recurrent abnormal uterine bleeding may benefit from planned menstrual cycling with Provera.
Tablets are stored at 68 F to 77 F (20 C to 25 C).
The Provera label gives no missed-dose rule. Neither the prescribing information nor the Patient Information says what to do if a dose is missed.
In Dose Track you set up Provera as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.