Short answer: The Climara Pro label dose is one patch (0.045 mg estradiol and 0.015 mg levonorgestrel per day) applied once weekly to the lower abdomen or upper buttock, for hot flashes or to prevent osteoporosis. Only one patch is worn at a time. The label calls for the lowest effective dose for the shortest duration, and attempts to stop at 3 to 6 month intervals.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Climara Pro is approved for: Climara Pro is a weekly patch with an estrogen (estradiol) and a progestin (levonorgestrel). It is approved for a woman with a uterus to treat moderate to severe hot flashes due to menopause and to prevent postmenopausal osteoporosis (sections 1.1, 1.2). For bone alone, the label says to first consider non-estrogen medicines, and estrogen only for women at significant risk of osteoporosis.
Source
CLIMARA PRO (estradiol/levonorgestrel transdermal system), prescribing information, Patient Information and Instructions for Use. Bayer HealthCare Pharmaceuticals. DailyMed, version published March 30, 2026. DailyMed setid 184d3092-7fc6-4375-816b-1ab06bb99cfd
Climara Pro goes on a smooth, clean, dry area of the lower abdomen or the upper quadrant of the buttock, not on or near the breasts, not on the waistline and not where sitting would rub it off. Sites are rotated, at least 1 week apart (section 2.3).
The patch is applied right after the pouch is opened and pressed firmly for at least 10 seconds. Only one patch is worn during the 7-day interval. Swimming, bathing or sauna use has not been studied and may reduce sticking and delivery (section 2.3).
Each 22 cm2 patch holds 4.4 mg estradiol and 1.39 mg levonorgestrel; a carton has 4 patches. It is stored at 20°C to 25°C (68°F to 77°F) in its pouch (sections 3, 16).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Use | Dose | How often |
|---|---|---|
| Moderate to severe hot flashes | Climara Pro 0.045 mg per day/0.015 mg per day | One patch applied once weekly |
| Prevention of postmenopausal osteoporosis | Climara Pro 0.045 mg per day/0.015 mg per day | One patch applied once weekly |
Estrogen, alone or with a progestogen, is used at the lowest effective dose for the shortest duration consistent with treatment goals and risks, with periodic re-evaluation of whether treatment is still needed.
For hot flashes, the label says attempts to discontinue Climara Pro should be made at 3 to 6 month intervals.
If a patch falls off, the same patch is put back on another area; if it cannot be, a new patch may be applied and the original schedule continued.
If feasible, estrogens are stopped at least 4 to 6 weeks before surgery linked to a higher risk of blood clots, or during long immobilization.
A pelvic exam, breast exam and mammogram every year are listed unless the healthcare provider says otherwise, and vaginal bleeding on treatment is reported right away.
The Patient Information says: "If you forget to apply a new Climara Pro, apply a new patch as soon as possible." The Instructions for Use add that stopping or forgetting a patch may bring spotting or bleeding, and symptoms may come back.
More on this: missed a dose of Climara Pro.
Women not on continuous estrogen or estrogen plus progestogen therapy may start at any time. Women on such therapy complete the current cycle first; the first day of withdrawal bleeding is a suitable time to start Climara Pro.
In Dose Track you set up Climara Pro as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.