Short answer: The Estring label dose is one ring inserted as deeply as possible into the upper third of the vagina and left in place continuously for three months. It then comes out and, if treatment continues, a new ring goes in. If the ring falls out during the 90 days, it is rinsed in lukewarm water and reinserted. Keeping it past 90 days gives a lower and lower dose.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Estring is approved for: Estring is a soft vaginal ring holding 2 mg of estradiol that releases about 7.5 mcg per day over 90 days. It is approved to treat moderate to severe symptoms of vulvar and vaginal atrophy (dryness, irritation and thinning of vaginal tissue) due to menopause (Indications and Usage, Description).
Source
ESTRING (estradiol vaginal system) prescribing information (Physician's Leaflet) and Patient Information. Pfizer. DailyMed, version published April 27, 2026. DailyMed setid 110b9865-5a07-4d45-b560-e89947f12600
The ring is pressed into an oval and inserted into the upper third of the vaginal vault. The exact position is not critical, and it should not be felt when in place (Dosage and Administration).
It stays in continuously for 90 days and should not interfere with intercourse. Straining at a bowel movement may push it lower; it can be pushed back up with a finger (Instructions for Use).
It is removed by hooking a finger through the ring and pulling it out (Instructions for Use).
Each ring contains 2 mg estradiol to deliver 7.5 mcg per day over 90 days (How Supplied).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Item | What the label says |
|---|---|
| Dose | One ring inserted as deeply as possible into the upper one-third of the vaginal vault |
| How long | Continuously for three months, then removed and, if appropriate, replaced |
| Release rate | About 7.5 mcg estradiol per day over 90 days |
| Ring contents | 2 mg estradiol |
| If it falls out | Rinse in lukewarm water and reinsert |
| Past 90 days | Not an overdose, but progressively greater underdosage |
Keeping the ring in longer than 90 days is not an overdose, but gives progressively less estradiol, with a risk of losing effect and a growing risk of vaginal infection and/or erosion.
Vaginal infections are treated before starting Estring. If one develops during use, the ring is removed and reinserted only after the infection has been treated.
If vaginal ulceration or erosion has occurred, the label says to consider leaving the ring out until healing is complete.
Serum FSH and estradiol levels have not been shown to be useful in managing vulvar and vaginal atrophy.
There is no daily dose to miss. If the ring is removed or falls out during the 90 days, it is rinsed in lukewarm water and reinserted, by the patient or, if needed, a doctor or nurse (Dosage and Administration).
In Dose Track you set up Estring as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.