Glutathione is a small molecule made of three amino acids (glutamate, cysteine and glycine) that the body makes itself. It is the main antioxidant inside cells. It is sold as an oral supplement and, from compounding pharmacies, as an injection.
Also known as: GSH, reduced glutathione.
There is no FDA-approved glutathione product, so strengths vary; use the amount on your label. Human studies used 2 g per square meter of body surface by vein (Aebi 1991), about 3 g once by mouth (Witschi 1992), and 250 or 1,000 mg a day by mouth for 6 months (Richie 2015). These are study protocols, not a recommendation.
Glutathione is not an FDA-approved drug. Oral glutathione is sold as a dietary supplement, and FDA does not approve dietary supplements before they are marketed. For compounding, glutathione sits in FDA's 503A Category 1 (bulk substances under evaluation, list updated May 14, 2026).
Oral glutathione is largely broken down in the gut and liver: a single dose of about 3 g did not raise blood levels significantly (Witschi 1992). In a 6-month trial, 1,000 mg a day raised body stores by about 30 to 35%, returning to baseline a month after stopping (Richie 2015).
We found no published human half-life for glutathione injected under the skin, which is the route the app uses. Given by vein at a high dose (Aebi 1991), glutathione cleared from plasma with a half-life of about 14 minutes, much shorter than the app's 1.5-hour modeling value, so we do not list a number.