How to Store Soliqua 100/33 Pens: Fridge, 28 Days
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How to store Soliqua 100/33

Quoted from the US label · Unopened vs in use · Travel · Sources · Reviewed

Short answer: Keep new Soliqua 100/33 pens in the fridge at 36-46°F (2-8°C), protected from light. After the first injection, keep the pen at room temperature up to 77°F (25°C), not back in the fridge, and throw it away 28 days after first use. Do not freeze it, and discard a pen that froze. Source: Soliqua label, section 16.2 and Instructions for Use.

What does the Soliqua label say?

Section 16.2: “Prior to first use, SOLIQUA 100/33 pen should be stored in a refrigerator, 36°F–46°F (2°C–8°C). Do not freeze. Discard SOLIQUA 100/33 if it has been frozen. Protect from light.” Then: “After first use, store at room temperature up to 77°F (25°C). Replace the pen cap after each use to protect from light. Discard pen 28 days after first use.”

Soliqua 100/33 US prescribing information, section 16.2, and Instructions for Use.
FormBefore first useAfter first use
3 mL single-patient-use penRefrigerator, 36-46°F (2-8°C), protected from lightRoom temperature up to 77°F (25°C); not back in the fridge; discard after 28 days

How do you handle a Soliqua pen once it is in use?

  • Instructions for Use: take a new pen out of the refrigerator at least 1 hour before you inject; “Cold medicine is more painful to inject.”
  • After first use: “Keep your pen at room temperature, up to 77°F (25°C). Do not put your pen back in the refrigerator.”
  • Remove the needle after each injection and store the pen without a needle attached, with the cap on (section 16.2 and Instructions for Use).
  • The 28 days count from the first injection, and the Medication Guide says to throw the pen away after 28 days even if some medicine is left.

Soliqua combines insulin glargine (the insulin in Lantus) with lixisenatide, a GLP-1 drug. The Lantus page has different in-use rules, so the two are not interchangeable for storage. For a missed dose, see missed a Soliqua dose.

What if Soliqua froze or got too warm?

Frozen: the label says discard Soliqua if it has been frozen, and the Instructions for Use say “If you accidentally freeze your pen, throw it away.”

Warm: room-temperature storage after first use stops at 77°F (25°C), and the label gives no room-temperature allowance for a pen that has not been used yet. Ask your pharmacist about a pen that went outside these limits. See also left out of the fridge.

How do you travel with it?

An in-use Soliqua pen travels at room temperature for the rest of its 28 days, but the ceiling is 77°F (25°C), lower than many pens, so an insulated bag helps in warm weather. Unused pens stay cold.

  • TSA allows medically necessary liquids over 3.4 oz in carry-on bags; declare them at the checkpoint for inspection.
  • Unused syringes and pen needles are allowed when they travel with the injectable medicine.
  • Ice packs and gel packs that keep medicine cool may go through frozen, partly frozen or melted.
  • Keep medicine in your carry-on, not checked luggage, where you cannot control the temperature. Do not let it touch an ice pack directly, since most labels say do not freeze.

More in the travel guide.

Quoted from the current US label on DailyMed, not personalized advice. Labels change; the leaflet in your own carton, your pharmacist and your prescriber are the final word on how to store it.
LantusUnopened in the fridge; 28 days once opened; in-use SoloStar pens at room temperature only. Xultophy 100/3.6Fridge until first use; then 21 days at 59-86°F or in the fridge. Left out of the fridgeExact room-temperature hours and days from each label, and the temperature ceiling. Traveling with injectablesTSA rules for liquids, syringes and ice packs, plus the label temperature limits to plan around.

Frequently asked questions

Does Soliqua need to be refrigerated?+
Before first use, yes: 36-46°F (2-8°C), protected from light. After first use, the pen is kept at room temperature up to 77°F (25°C) and not put back in the fridge.
How long is a Soliqua pen good after opening?+
28 days after first use, even if some medicine is left (section 16.2).
Can I put my Soliqua pen back in the fridge?+
No. The Instructions for Use say after first use, do not put your pen back in the refrigerator.
Can I use Soliqua that froze?+
No. The label says discard Soliqua if it has been frozen.

Sources

  1. Soliqua 100/33 (insulin glargine and lixisenatide) US prescribing information, DailyMed
  2. TSA: Liquid medications
  3. TSA: Unused syringes
  4. TSA: Gel ice packs

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