How to Store Elestrin Gel and Evamist Spray
[Storage · Elestrin and Evamist]

How to store Elestrin (estradiol gel) and Evamist (estradiol spray)

Quoted from the US label · Unopened vs in use · Travel · Sources · Reviewed

Short answer: Store Elestrin and Evamist at room temperature, 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C). Evamist also says do not freeze. Throw away an Elestrin pump after priming and 30 doses, and an Evamist applicator after 56 sprays, even if not empty. Both contain alcohol and are flammable until dry. Sources: both labels, section 16.2 and patient leaflets.

What do the labels say?

Elestrin, section 16.2: “Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature].” The Elestrin Patient Information has no storage section; the carton repeats the temperature and says the container is not child-resistant.

Evamist, section 16.2: “Store at room temperature 20°C to 25°C (68°F to 77°F); excursion permitted between 15°C to 30°C (59°F to 86°F). Do not freeze.” Its Patient Information adds: “Safely throw away medicine that is out of date or no longer needed.”

Elestrin 0.06% and Evamist US prescribing information, section 16, and patient leaflets.
QuestionElestrin gel 0.06%Evamist spray
Temperature68-77°F (20-25°C); excursions 59-86°F (15-30°C)68-77°F (20-25°C); excursions 59-86°F (15-30°C)
FreezingNot statedDo not freeze
RefrigeratorNot statedNot stated
Container35 g metered-dose pump; delivers 26 g as 30 doses of 0.87 g; 2 pumps per carton8.1 mL glass vial with metered-dose pump; 56 sprays of 90 mcL after priming
PrimingUntil gel comes out; throw that gel away5 sprays with the cover on, once per new applicator
When to throw it awayAfter priming and 30 dosesAfter 56 application sprays
FlammableYes, until the gel has driedYes, until the spray has dried

When do you throw away the pump or applicator?

Elestrin Patient Information: “After you have initially primed the pump and have used a total of 30 doses of ELESTRIN, you will need to throw the pump away and use a new one. The correct amount of medicine in each dose cannot be assured after 30 doses have been used, even though the pump container is not completely empty.” Gel pumped out while priming is thrown away in the trash so that another person or a pet cannot touch, eat or drink it. After each use, the spout goes into the locked position and the cap goes back on.

Evamist Instructions for Use: “Do not use your EVAMIST applicator for more than 56 application sprays even though the bottle may not be completely empty. You may not get the correct dose.” Put the cover back over the cone before throwing the applicator away, to prevent accidental exposure to other people or pets.

See Elestrin side effects, Evamist side effects, the Elestrin and Evamist dosing schedules, missed an Elestrin dose, and the EstroGel and Divigel gels.

How do you travel with them?

Both are room-temperature products, so they need no ice pack. Keep them in your carry-on, within 59-86°F (15-30°C), and out of a hot car; keep Evamist from freezing. Both contain alcohol: the labels say avoid fire, flame or smoking until the gel or spray has dried.

  • TSA allows medically necessary liquids and gels over 3.4 oz in carry-on bags; declare them at the checkpoint for inspection.
Quoted from the current US label on DailyMed, not personalized advice. Labels change; the leaflet in your own carton, your pharmacist and your prescriber are the final word on how to store it.

Frequently asked questions

Does Elestrin need to be refrigerated?+
No. The label says store it at 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C).
Can Evamist be frozen?+
No. The Evamist label and Patient Information say do not freeze. Store it at 68-77°F (20-25°C).
Why throw away the pump or applicator before it is empty?+
The labels say the correct dose cannot be assured after 30 Elestrin doses or 56 Evamist sprays.
Is estradiol gel or spray flammable?+
Yes. Both labels say the products contain alcohol: avoid fire, flame or smoking until the gel or spray has dried.