Short answer: The Sprycel label says that if you miss a dose, take the next scheduled dose at its regular time. Do not take two doses at the same time. The Patient Information says the same. Adults usually take 100 mg or 140 mg once a day, depending on the type of leukemia.
| Situation | What the label says |
|---|---|
| Schedule | 100 mg or 140 mg once daily for adults, morning or evening; children by weight (2.1, 2.2) |
| Missed a dose | Take the next scheduled dose at its regular time (17) |
| Doubling up | Do not take two doses at the same time (17, Patient Information) |
| Half-life | 3 to 5 hours (12.3) |
Section 17 says that if patients miss a dose of Sprycel, they should take the next scheduled dose at its regular time, and should not take two doses at the same time. The Patient Information says the same: if you miss a dose, take your next scheduled dose at your regular time.
Unlike many daily tablets, the label does not offer a window to take the missed dose late.
The Patient Information says to take Sprycel once a day, in the morning or the evening, with or without a meal, and to swallow the tablets whole without crushing, cutting or chewing them. It also says not to drink grapefruit juice during treatment.
Section 12.3 gives a mean terminal half-life of 3 to 5 hours for dasatinib.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.