Dasatinib (Sprycel): Label and Senolytic Studies
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Dasatinib: label, half-life and senolytic studies

Tablet strengths · Approval status · Half-life ~3 to 5 hours

Short answer: Dasatinib has a half-life of about 3 to 5 hours. Levels peak 0.5 to 6 hours after a dose. People vary, so treat these as estimates.

What is dasatinib?

Dasatinib is a kinase inhibitor, a targeted cancer drug sold as Sprycel tablets for two types of leukemia (Philadelphia chromosome-positive CML and ALL). Combined with quercetin ("D+Q"), it has been studied off-label as a senolytic, a drug meant to clear senescent ("zombie") cells that build up with age.

Also known as: Sprycel.

Tablet strengths

Sprycel comes as 20 mg, 50 mg, 70 mg, 80 mg, 100 mg and 140 mg tablets.

Approval status and how it is used

The FDA Sprycel label approves dasatinib for adults with newly diagnosed or treatment-resistant Philadelphia chromosome-positive chronic myeloid leukemia (CML) or resistant acute lymphoblastic leukemia (ALL), and for children 1 year and older with chronic-phase CML or, with chemotherapy, newly diagnosed ALL. The adult starting dose is 100 mg once a day for chronic-phase CML and 140 mg once a day for advanced CML or ALL. Warnings include low blood counts, bleeding, fluid retention (including fluid around the lungs), heart problems, pulmonary arterial hypertension, QT prolongation, severe skin reactions, tumor lysis syndrome, harm to an unborn baby and liver injury. Stomach-acid reducers (H2 blockers and proton pump inhibitors) lower its absorption, and grapefruit juice and strong CYP3A4 blockers raise its levels.

Senolytic use is off-label and the trials are small. In an open-label pilot in 14 people with idiopathic pulmonary fibrosis (Justice, 2019), dasatinib 100 mg plus quercetin 1,250 mg a day, 3 days a week for 3 weeks, was followed by better walking and chair-stand scores. In 9 people with diabetic kidney disease (Hickson, 2019), 3 days of dasatinib 100 mg plus quercetin 1,000 mg lowered markers of senescent cells in fat and skin 11 days later. A placebo-controlled pilot in 12 people with pulmonary fibrosis (Nambiar, 2023) found D+Q feasible and generally tolerated, with more mild side effects than placebo (sleep problems and anxiety in 4 of 6 versus 0 of 6) and no clear difference in function. These are study protocols, not personalized advice; confirm any dosing with your prescriber.

Dasatinib half-life and time to peak

  • Half-lifeabout 3 to 5 hours
  • Time to peak (Tmax)0.5 to 6 hours

The FDA Sprycel label gives a mean terminal half-life of 3 to 5 hours, with peak levels 0.5 to 6 hours after a dose. A dose of the proton pump inhibitor omeprazole taken 22 hours earlier cut dasatinib exposure by 43%. The 2019 kidney study called its few-day course "hit-and-run" treatment, noting that both drugs have half-lives under 11 hours.

Numbers shown are taken from the source above. Half-life varies from person to person.

How to track dasatinib in Dose Track

  1. Add dasatinib as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each tablet when you take it, including split or fractional tablets, so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Quercetinquercetin dihydrate, quercetin phytosome Fisetinhalf-life about 1.1 hours FOXO4-DRI Rapamycinsirolimus, Rapamune · half-life about 62 hours (about 2.6 days)

Frequently asked questions

What is the half-life of dasatinib?+
The FDA Sprycel label gives a mean terminal half-life of 3 to 5 hours, with peak levels 0.5 to 6 hours after a dose. A dose of the proton pump inhibitor omeprazole taken 22 hours earlier cut dasatinib exposure by 43%. The 2019 kidney study called its few-day course "hit-and-run" treatment, noting that both drugs have half-lives under 11 hours.
What is D+Q?+
Dasatinib plus quercetin, a combination studied as a senolytic. Human trials so far are small pilots in pulmonary fibrosis and diabetic kidney disease, using dasatinib 100 mg with 1,000 to 1,250 mg of quercetin for a few days at a time. It is not an approved use.
What should not be taken with dasatinib?+
The FDA Sprycel label says not to take H2 blockers or proton pump inhibitors with it, to keep antacids at least 2 hours away from a dose, and to avoid grapefruit juice and strong CYP3A4 blockers.
Can I track dasatinib in Dose Track?+
Yes. Dasatinib is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each tablet next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Sprycel (dasatinib) tablets prescribing information (Bristol-Myers Squibb), sections 1, 2, 3, 5, 7 and 12.3. DailyMed, September 2026.
  2. Justice JN, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554-563.
  3. Hickson LJ, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446-456.
  4. Nambiar A, et al. Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine. 2023;90:104481.

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