Short answer: The naltrexone tablets label has no missed-dose instructions. It describes 50 mg once daily for most people. It does mention missed doses once: people treated for opioid use disorder may be at risk of opioid overdose after a dose is missed, so the label asks prescribers to discuss naloxone. Ask your prescriber or pharmacist what to do.
| Situation | What the label says |
|---|---|
| Schedule | 50 mg once daily for most people; other supervised schedules are listed (Dosage and Administration) |
| Missed-dose rule | None in the label |
| After a missed dose | Risk of opioid overdose for people treated for opioid use disorder (Dosage and Administration, Warnings) |
| Half-life | Naltrexone about 4 hours; 6-beta-naltrexol about 13 hours (Clinical Pharmacology) |
No. We checked the naltrexone hydrochloride tablets prescribing information from SpecGx on DailyMed. It has no missed-dose instructions and no patient leaflet. The Dosage and Administration section gives 50 mg once daily for most people, with supervised schedules such as 100 mg every other day or 150 mg every third day also listed.
The Dosage and Administration section says that people being treated for opioid use disorder may relapse, "putting them at risk for opioid overdose after naltrexone hydrochloride treatment is discontinued, or after a dose of naltrexone hydrochloride is missed," and asks prescribers to strongly consider an overdose reversal agent such as naloxone.
The Clinical Pharmacology section gives mean elimination half-lives of 4 hours for naltrexone and 13 hours for its main active metabolite, 6-beta-naltrexol. Low-dose use is outside the label, so the label has no schedule or missed-dose rule for it.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.