Short answer: 10 mg of tirzepatide is 200 units on a U-100 syringe at 5 mg/mL, 125 units at 8 mg/mL, 100 units at 10 mg/mL, 66.67 units at 15 mg/mL and 50 units at 20 mg/mL. In volume that is 2 mL at 5 mg/mL, 1.25 mL at 8 mg/mL, 1 mL at 10 mg/mL, 0.6667 mL at 15 mg/mL and 0.5 mL at 20 mg/mL. Compounded products are not FDA approved; check the strength on your vial label, because the units are only right for that strength.
Each row converts 10 mg at one compounded tirzepatide strength for a U-100 insulin syringe (1 mL = 100 units). Not personalized advice; confirm your dose, in mg and in units, with your prescriber or the dispensing pharmacy.
| Vial strength | Volume | U-100 units | Smallest syringe that holds it |
|---|---|---|---|
| 5 mg/mL | 2 mL | 200 units | More than one 1 mL syringe |
| 8 mg/mL | 1.25 mL | 125 units | More than one 1 mL syringe |
| 10 mg/mL | 1 mL | 100 units | 1 mL (100 units) |
| 15 mg/mL | 0.6667 mL | 66.67 units (between marks) | 1 mL (100 units) |
| 20 mg/mL | 0.5 mL | 50 units | 0.5 mL (50 units) |
"Between marks" means the volume does not land on a printed line, even on a 0.3 mL syringe with half-unit markings. See U-40 vs U-100 syringes and how to read the marks.
Divide the dose by the strength to get mL, then multiply by 100 for U-100 units. To check, run it backwards: units ÷ 100 × mg/mL should give back 10 mg.
10 mg ÷ 5 mg/mL = 2 mL × 100 = 200 units; check: 200 ÷ 100 × 5 = 10 mg10 mg ÷ 8 mg/mL = 1.25 mL × 100 = 125 units; check: 125 ÷ 100 × 8 = 10 mg10 mg ÷ 10 mg/mL = 1 mL × 100 = 100 units; check: 100 ÷ 100 × 10 = 10 mg10 mg ÷ 15 mg/mL = 0.6667 mL × 100 = 66.67 units; check: 66.67 ÷ 100 × 15 = about 10 mg10 mg ÷ 20 mg/mL = 0.5 mL × 100 = 50 units; check: 50 ÷ 100 × 20 = 10 mgIf the units on your instructions do not match this math for the strength on your vial, ask the prescriber or pharmacy before injecting.
In the Mounjaro label, 10 mg is dose step 4 of 6. The schedule has no fixed weeks for 10 mg; the label reaches it with this step: Further steps: If more glycemic control is needed, increase by 2.5 mg after at least 4 weeks on the current dose. The label also says: For pediatric patients 10 years and older the Mounjaro label sets a lower maximum of 10 mg once weekly. (Mounjaro label)
In the Zepbound label, 10 mg is dose step 4 of 6. The label schedule lists it as Maintenance: 5 mg, 10 mg or 15 mg once weekly for weight reduction; 10 mg or 15 mg for obstructive sleep apnea. (Zepbound label)
Compounded tirzepatide has no FDA label of its own. For reference, these are the schedules in the FDA labels that name 10 mg, with its rows highlighted.
| When | Label dose |
|---|---|
| Weeks 1 to 4 | 2.5 mg once weekly (for starting treatment only) |
| Week 5 | 5 mg once weekly |
| Further steps | Increase by 2.5 mg after at least 4 weeks on the current dose |
| Maintenance | 5 mg, 10 mg or 15 mg once weekly for weight reduction; 10 mg or 15 mg for obstructive sleep apnea |
| Maximum | 15 mg once weekly |
The label states that 2.5 mg is for starting treatment and is not an approved maintenance dose.
| When | Label dose |
|---|---|
| Start | 2.5 mg once weekly |
| Further steps | If more glycemic control is needed, increase by 2.5 mg after at least 4 weeks on the current dose |
| Maximum | 15 mg once weekly in adults |
For pediatric patients 10 years and older the Mounjaro label sets a lower maximum of 10 mg once weekly.
Full schedules: Mounjaro dosing schedule · Zepbound dosing schedule
Previous step: 7.5 mg · Next step: 12.5 mg
2.5 mg · 5 mg · 7.5 mg · 12.5 mg · 15 mg · All tirzepatide doses and strengths in one grid
Mixing a powder vial instead? The tirzepatide reconstitution guide and the free reconstitution calculator handle vials you add water to.