Short answer: The Toujeo label gives one injection under the skin once a day at the same time of day. In type 2 diabetes not already on insulin it starts at 0.2 units/kg once daily. In type 1 it starts at about one-third to one-half of total daily insulin, with mealtime insulin for the rest. The dose is changed no more often than every 3 to 4 days. The label has no missed-dose rule.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Toujeo is approved for: Toujeo is a long-acting insulin approved to improve blood sugar control in adults and children 6 years and older with diabetes (section 1). It is not recommended for treating diabetic ketoacidosis.
Source
TOUJEO (insulin glargine) injection, for subcutaneous use, 300 units/mL, prescribing information, Patient Information and Instructions for Use. Sanofi-Aventis U.S.. DailyMed, version published June 12, 2025. DailyMed setid c9561d96-124d-48ca-982f-0aa1575bff36
Toujeo is injected under the skin of the abdomen, thigh or deltoid (upper arm) once a day at the same time of day, rotating sites within the same area. It is not given into a vein or by insulin pump, and not diluted or mixed with other insulins (sections 2.1 and 2.2).
It comes as U-300 (300 units/mL) in two pens: the 1.5 mL SoloStar (450 units, 1-unit steps, up to 80 units per injection) and the 3 mL Max SoloStar (900 units, 2-unit steps, up to 160 units per injection), recommended for people needing at least 20 units a day. The dose counter shows units with no conversion needed (sections 2.2 and 3).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Situation | What the label says |
|---|---|
| When to inject | Once a day at the same time of day |
| Type 1 diabetes, not on insulin, starting dose | About one-third to one-half of the total daily insulin dose; short-acting insulin divided between meals for the rest. 0.2 to 0.4 units/kg can be used to estimate the total daily dose |
| Type 2 diabetes, not on insulin, starting dose | 0.2 units/kg once daily |
| Switching from once-daily long or intermediate-acting insulin | Same unit dose; from Lantus, expect a higher Toujeo dose to be needed |
| Switching from twice-daily NPH or insulin detemir | 80% of the total daily dose |
| How often the dose is changed | No more frequently than every 3 to 4 days |
| Pen | Unopened, refrigerated 36-46 F | Opened (in use), room temperature up to 86 F, not refrigerated |
|---|---|---|
| 1.5 mL SoloStar | Until expiration date | 56 days |
| 3 mL Max SoloStar | Until expiration date | 56 days |
When changing between SoloStar and Max SoloStar, an odd-numbered dose is raised or lowered by 1 unit to match the Max SoloStar's 2-unit steps.
The maximum glucose-lowering effect of a dose may take five days to show, and the first dose may not cover needs in the first 24 hours; glucose is checked daily when starting.
Glucose is monitored often in the first weeks after switching to Toujeo.
In type 1 diabetes on IV insulin, the label says to consider Toujeo's slower onset before stopping the IV insulin.
Pens are not frozen, and a pen that has frozen is thrown away. In-use pens are kept with the cap on and protected from direct heat and light.
The Toujeo label gives no missed-dose rule. Neither the prescribing information nor the Patient Information says what to do if a dose is missed; it says Toujeo is used once a day at the same time each day.
More on this: missed a dose of Toujeo.
From once-daily long or intermediate-acting insulin, Toujeo starts at the same unit dose; from Lantus, a higher daily Toujeo dose is expected to be needed. From twice-daily NPH or insulin detemir, it starts at 80% of the total daily dose.
Unit for unit, Toujeo lowers glucose less than Lantus. In trials, people switched to Toujeo had higher fasting glucose in the first weeks than those switched to Lantus.
In Dose Track you set up Toujeo as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.