Short answer: The Semglee label gives one injection under the skin once a day, at any time of day but at the same time every day. In type 1 diabetes it starts at about one-third of total daily insulin, with short-acting mealtime insulin for the rest. In type 2 diabetes not on insulin it starts at 0.2 units/kg or up to 10 units once daily. The label has no missed-dose rule.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Semglee is approved for: Semglee is a long-acting insulin approved to improve blood sugar control in adults and children with diabetes (section 1). It is not recommended for treating diabetic ketoacidosis.
Source
SEMGLEE (insulin glargine-yfgn) injection, for subcutaneous use, prescribing information, Patient Information and Instructions for Use. Biocon Biologics. DailyMed, version published April 17, 2026. DailyMed setid 8cf5544f-87d6-468b-f6ae-898b1fdb5d80
Semglee is injected under the skin of the abdomen, thigh or deltoid (upper arm) once a day at the same time every day, rotating sites within the same region. In type 1 diabetes it is always used with a short-acting insulin. It is not diluted or mixed with any other insulin or solution, and not given into a vein or by insulin pump (sections 2.1 and 2.2).
It comes as U-100 (100 units/mL) in a 10 mL multiple-dose vial and a 3 mL prefilled pen that dials in 1-unit steps (sections 2.1 and 3).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Situation | What the label says |
|---|---|
| When to inject | Once daily at any time of day, at the same time every day |
| Type 1 diabetes, starting dose | About one-third of total daily insulin; short-acting premeal insulin for the rest |
| Type 2 diabetes, not on insulin, starting dose | 0.2 units/kg or up to 10 units once daily |
| Switching from once-daily insulin glargine 300 units/mL | 80% of the glargine 300 units/mL dose being stopped |
| Switching from once-daily NPH | Same dose as the NPH being stopped |
| Switching from twice-daily NPH | 80% of the total NPH dose being stopped |
| Presentation | Unopened, refrigerated 36-46 F | Unopened, room temp up to 86 F | In use (opened) |
|---|---|---|---|
| 10 mL multiple-dose vial | Until expiration date | 28 days | 28 days, refrigerated or room temperature |
| 3 mL prefilled pen | Until expiration date | 28 days | 28 days, room temperature only (do not refrigerate) |
The dose is individualized by metabolic needs, glucose monitoring and glucose goal. Changes may be needed with changes in activity, meals, acute illness or kidney or liver function, and are made only under medical supervision with glucose monitoring.
The label recommends dose adjustments when switching to Semglee from other insulins to lower the risk of low blood sugar.
Glucose is monitored more often during any change to the insulin regimen. The solution should be clear and colorless. The label advises caution with the pen for people with poor vision who rely on its clicks.
Semglee is never frozen and is thrown away if it has been. It is protected from direct heat and light.
The Semglee label gives no missed-dose rule. Neither the prescribing information nor the Patient Information says what to do if a dose is missed; the label says Semglee is injected once daily at the same time every day.
More on this: missed a dose of Semglee.
From once-daily insulin glargine 300 units/mL, Semglee starts at 80% of that dose. From once-daily NPH, it starts at the same dose. From twice-daily NPH, it starts at 80% of the total NPH dose.
Any change of insulin strength, maker, type, site or method is made under close medical supervision with more frequent glucose checks. In type 2 diabetes, doses of other diabetes medicines may need adjusting.
In Dose Track you set up Semglee as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.