Short answer: The Evenity label dose is 210 mg injected under the skin once every month for 12 doses, given by a healthcare provider as two 105 mg syringes one after the other, in the abdomen, thigh or upper arm. Calcium and vitamin D are taken during treatment. A missed dose is given as soon as it can be rescheduled, then monthly from that date.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Evenity is approved for: Evenity is a sclerostin inhibitor approved to treat osteoporosis in postmenopausal women at high risk for fracture: a past osteoporotic fracture, several risk factors, or other osteoporosis treatments that failed or were not tolerated (section 1.1). Because its bone-building effect wanes, use is limited to 12 monthly doses, after which an anti-resorptive medicine may be considered (section 1.2).
Source
EVENITY (romosozumab-aqqg) injection, for subcutaneous use, prescribing information and Medication Guide. Amgen. DailyMed, version published August 3, 2026. DailyMed setid 471baba2-7154-4488-9891-0db2f46791e7
Each monthly dose of 210 mg is two separate injections under the skin from two 105 mg/1.17 mL prefilled syringes, given one after the other by a healthcare provider (section 2.1).
Injection sites are the thigh, the abdomen except a two-inch area around the navel, or the outer upper arm, with a separate site for each of the two injections. The syringes sit at room temperature for at least 30 minutes first (section 2.3).
Treatment lasts 12 monthly doses, because the bone-building effect wanes after that (sections 1.2 and 2.2).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Item | What the label says |
|---|---|
| Dose | 210 mg administered subcutaneously once every month |
| How it is given | Two 105 mg/1.17 mL prefilled syringes injected one after the other, by a healthcare provider |
| Injection site | Abdomen, thigh or upper arm |
| Length of treatment | 12 monthly doses |
| Calcium and vitamin D | Adequately supplemented during treatment |
| Missed dose | Administer as soon as it can be rescheduled; then every month from the date of the last dose |
| After 12 doses | If osteoporosis therapy remains warranted, continued therapy with an anti-resorptive agent should be considered |
Evenity is not started within a year of a heart attack or stroke, and is stopped if one occurs during treatment.
Low blood calcium is corrected before starting.
In severe kidney impairment or on dialysis, serum calcium is monitored and calcium and vitamin D are supplemented.
A routine oral exam is done before starting.
In the trials, women took at least 500 mg calcium and 600 IU vitamin D daily, and about three quarters received a vitamin D loading dose if their level was 40 ng/mL or less.
If an Evenity dose is missed, it is given as soon as it can be rescheduled. After that, doses are scheduled every month from the date of the last dose. The Medication Guide says to contact your healthcare provider as soon as possible to schedule the next dose.
More on this: missed a dose of Evenity.
After 12 monthly doses, if osteoporosis treatment is still needed, the label says an anti-resorptive medicine should be considered.
In Dose Track you set up Evenity as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.