Short answer: Jentadueto is taken by mouth twice daily with meals. Without current metformin, the label starts at 2.5 mg linagliptin/500 mg metformin twice daily, raised gradually to reduce stomach side effects. The maximum is 2.5 mg/1,000 mg twice daily. Starting is not recommended with an eGFR of 30 to 45, and it is not used below 30. The Medication Guide says a missed dose is taken with food when remembered unless the next dose is due.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Jentadueto is approved for: Jentadueto combines linagliptin, a DPP-4 inhibitor, with metformin, a biguanide. It is approved, along with diet and exercise, to improve blood sugar control in adults with type 2 diabetes (section 1). It is not recommended in type 1 diabetes, and it has not been studied in people who have had pancreatitis.
Source
JENTADUETO (linagliptin and metformin hydrochloride tablets), for oral use, prescribing information and Medication Guide. Boehringer Ingelheim Pharmaceuticals. DailyMed, version published August 26, 2026. DailyMed setid f6dd9b86-0d18-95d4-2bc7-05591bfdd597
Jentadueto is a tablet taken by mouth twice daily with meals. Dose increases are gradual to reduce stomach side effects from metformin (section 2.1).
It comes as 2.5 mg linagliptin with 500 mg, 850 mg or 1,000 mg metformin (section 3).
The dose is set by effectiveness and tolerability (section 2.1).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Current treatment | Jentadueto starting dose |
|---|---|
| Not treated with metformin HCl | 2.5 mg linagliptin/500 mg metformin HCl twice daily |
| Already treated with metformin HCl | 2.5 mg linagliptin and the current dosage of metformin HCl taken at each of the two daily meals (e.g., metformin HCl 1,000 mg twice daily starts on 2.5 mg linagliptin/1,000 mg metformin HCl twice daily with meals) |
| Already treated with linagliptin and metformin HCl as separate components | Jentadueto containing the same dosages of each component |
| Maximum recommended dosage | 2.5 mg linagliptin/1,000 mg metformin hydrochloride (HCl), taken orally twice daily |
Kidney function is assessed before starting and periodically after. Jentadueto is contraindicated with an eGFR below 30 mL/min/1.73 m2, and starting it at 30 to 45 is not recommended. If eGFR later falls below 45, benefit and risk of continuing are assessed; if it falls below 30, Jentadueto is stopped.
It is stopped at the time of, or before, an iodinated contrast scan with an eGFR of 30 to 60, a history of liver disease, alcoholism or heart failure, or intra-arterial contrast. eGFR is rechecked 48 hours after, and it is restarted if kidney function is stable.
Jentadueto is stopped for a time while food and fluid intake is restricted for surgery or other procedures.
With insulin or a sulfonylurea, a lower dose of those medicines may be needed to reduce the risk of low blood sugar.
Tablets are stored at 20 to 25 C (68 to 77 F), with excursions from 15 to 30 C allowed.
The dosing section has no missed-dose rule. Section 17 says a missed dose is taken as soon as the patient remembers, and the next dose is not doubled. The Medication Guide says: if you miss a dose, take it with food as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take 2 doses of Jentadueto at the same time.
More on this: missed a dose of Jentadueto.
People already on metformin start with linagliptin 2.5 mg plus their current metformin dose at each of the two daily meals. People taking linagliptin and metformin as separate tablets can switch to Jentadueto with the same dose of each.
In Dose Track you set up Jentadueto as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.