Short answer: Jentadueto XR is taken by mouth once daily with a meal and swallowed whole. Without current metformin, the label starts at 5 mg linagliptin/1,000 mg metformin once daily. The maximum is 5 mg linagliptin and 2,000 mg metformin a day, raised gradually to reduce stomach side effects. It is not used with an eGFR below 30. A missed dose is taken when remembered, without doubling the next.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Jentadueto XR is approved for: Jentadueto XR combines linagliptin, a DPP-4 inhibitor, with extended-release metformin, a biguanide. It is approved, along with diet and exercise, to improve blood sugar control in adults with type 2 diabetes (section 1). It is not recommended in type 1 diabetes, and it has not been studied in people who have had pancreatitis.
Source
JENTADUETO XR (linagliptin and metformin hydrochloride extended-release tablets), for oral use, prescribing information and Medication Guide. Boehringer Ingelheim Pharmaceuticals. DailyMed, version published August 27, 2026. DailyMed setid 3d02a4d4-d312-80b4-05c4-691b8f0aa7aa
Jentadueto XR is taken by mouth once daily with a meal. Dose increases are gradual to reduce stomach side effects from metformin (section 2.1).
Tablets are swallowed whole and never split, crushed, dissolved or chewed. Partly dissolved tablets may come out in the stool (sections 2.1 and 17).
It comes as 5 mg linagliptin/1,000 mg metformin (one tablet a day) and 2.5 mg linagliptin/1,000 mg metformin (two tablets taken together once a day) (sections 2.1 and 3).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Current treatment | Jentadueto XR starting dose |
|---|---|
| Not treated with metformin HCl | 5 mg linagliptin/1,000 mg metformin HCl extended-release once daily with a meal |
| Already treated with metformin HCl | 5 mg of linagliptin total daily dosage and a similar total daily dosage of metformin HCl once daily with a meal |
| Already treated with linagliptin and metformin HCl or JENTADUETO | Switch to JENTADUETO XR containing 5 mg of linagliptin total daily dosage and a similar total daily dosage of metformin HCl once daily with a meal |
| Maximum recommended total daily dosage | Linagliptin 5 mg and metformin hydrochloride (HCl) 2,000 mg |
| Tablet | How it is taken |
|---|---|
| 5 mg linagliptin/1,000 mg metformin HCl extended-release | A single tablet once daily |
| 2.5 mg linagliptin/1,000 mg metformin HCl extended-release | Two tablets together once daily |
Kidney function is assessed before starting and periodically after. Jentadueto XR is contraindicated with an eGFR below 30 mL/min/1.73 m2, and starting it at 30 to 45 is not recommended. If eGFR later falls below 45, benefit and risk of continuing are assessed; if it falls below 30, Jentadueto XR is stopped.
It is stopped at the time of, or before, an iodinated contrast scan with an eGFR of 30 to 60, a history of liver disease, alcoholism or heart failure, or intra-arterial contrast. eGFR is rechecked 48 hours after, and it is restarted if kidney function is stable.
Jentadueto XR is stopped for a time while food and fluid intake is restricted for surgery or other procedures.
With insulin or a sulfonylurea, a lower dose of those medicines may be needed to reduce the risk of low blood sugar.
Tablets are stored at 20 to 25 C (68 to 77 F), with excursions from 15 to 30 C allowed, protected from high humidity.
The dosing section has no missed-dose rule. Section 17 says a missed dose is taken as soon as the patient remembers, and the next dose is not doubled. The Medication Guide says: "If you miss a dose, take it with food as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take 2 doses of JENTADUETO XR at the same time."
More on this: missed a dose of Jentadueto XR.
People already on metformin start with 5 mg linagliptin a day and a similar total daily metformin dose, once daily with a meal. People taking linagliptin and metformin separately, or immediate-release Jentadueto, switch to Jentadueto XR with 5 mg linagliptin a day and a similar total daily metformin dose.
In Dose Track you set up Jentadueto XR as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.
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