Short answer: The Invokana label dose is 100 mg by mouth once daily, before the first meal of the day. For extra blood sugar control, it may go up to 300 mg in people tolerating 100 mg with an eGFR of 60 or more. For heart and kidney uses the dose is 100 mg. It is held for at least 3 days before surgery when possible. A missed dose is taken as soon as possible, without doubling.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Invokana is approved for: Invokana is an SGLT2 inhibitor approved, with diet and exercise, to improve blood sugar in adults and children 10 and older with type 2 diabetes; to lower the risk of major heart events in adults with type 2 diabetes and heart disease; and to lower the risk of end-stage kidney disease, doubling of creatinine, cardiovascular death and heart failure hospitalization in adults with type 2 diabetes and diabetic kidney disease with albuminuria over 300 mg/day (section 1).
Source
INVOKANA (canagliflozin) tablets, for oral use, prescribing information and Medication Guide. Janssen Pharmaceuticals. DailyMed, version published June 15, 2026. DailyMed setid b9057d3b-b104-4f09-8a61-c61ef9d4a3f3
Invokana is a tablet taken by mouth once daily, before the first meal of the day. It comes in 100 mg and 300 mg tablets (sections 2.2 and 3).
Kidney function is checked before starting, and fluid loss is corrected first (section 2.1).
Starting Invokana for blood sugar is not recommended with an eGFR under 30 (sections 1 and 2.3).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Estimated Glomerular Filtration Rate [eGFR (mL/min/1.73 m2)] | Recommended Dosage |
|---|---|
| eGFR 30 to less than 60 | The maximum recommended dosage is 100 mg orally once daily. |
| eGFR less than 30 | Initiation is not recommended. Adult patients taking INVOKANA with albuminuria greater than 300 mg/day may continue INVOKANA 100 mg once daily to reduce the risk of ESKD, doubling of serum creatinine, CV death, and hospitalization for heart failure. |
With an eGFR of 60 or more, the standard schedule applies: 100 mg once daily, which may go to 300 mg for extra blood sugar control (section 2.2).
For blood sugar control in adults and children 10 and older, the starting dose is 100 mg once daily, and it may be raised to the maximum of 300 mg once daily for more control. For the heart and kidney uses in adults, the dose is 100 mg once daily.
With a UGT inducer such as rifampin, phenytoin, phenobarbital or ritonavir: with eGFR 60 or more, the dose goes to 200 mg in people tolerating 100 mg (maximum 300 mg); with eGFR under 60, it goes to a maximum of 200 mg.
Invokana is withheld for at least 3 days, if possible, before surgery or procedures with prolonged fasting, and resumed when the person is stable and eating and drinking again.
A lower dose of insulin or a sulfonylurea may lower the risk of low blood sugar when used with Invokana.
No dose change is needed for mild or moderate liver impairment; Invokana is not recommended with severe liver impairment.
If a dose is missed, it is taken as soon as possible, and the next dose is not doubled. The Medication Guide adds: if it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time; do not take two doses at the same time.
More on this: missed a dose of Invokana.
In Dose Track you set up Invokana as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.