Short answer: Gvoke is a single rescue dose for severe low blood sugar, not a scheduled medicine. The label gives 1 mg under the skin for people 12 and older, and for children 2 to under 12 years, 0.5 mg under 45 kg or 1 mg at 45 kg or more. Emergency help is called right away, and a second dose from a new device may be given after 15 minutes with no response.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Gvoke is approved for: Gvoke (HypoPen, PFS and Kit) is approved to treat severe low blood sugar (severe hypoglycemia) in adults and children aged 2 and older with diabetes, given under the skin (section 1.1). Gvoke VialDx is a separate IV form used as a diagnostic aid during radiology exams in adults, to briefly slow movement of the gut (section 1.2).
Source
GVOKE (glucagon) injection, for subcutaneous use, and GVOKE VialDx (glucagon) injection, for intravenous use, prescribing information, Patient Information and Instructions for Use. Xeris Pharmaceuticals. DailyMed, version published October 23, 2026. DailyMed setid 92385737-dbad-98c5-e053-2995a90a2805
Gvoke is injected under the skin of the lower abdomen, outer thigh or outer upper arm as soon as severe low blood sugar is recognized. Because a person with severe hypoglycemia needs others to help, the label says the people around them are told about Gvoke and its Instructions for Use (section 2.1).
It comes as a ready-to-use solution in a 0.5 mg/0.1 mL or 1 mg/0.2 mL HypoPen auto-injector, a 1 mg/0.2 mL prefilled syringe (PFS) and a 1 mg/0.2 mL vial and syringe kit. Each holds one dose; any unused portion is thrown away (sections 2.1 and 3).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Who | Dose under the skin | If no response after 15 minutes |
|---|---|---|
| Adults and children 12 years and older | 1 mg | An additional 1 mg from a new device, while waiting for emergency help |
| Children 2 to under 12 years, under 45 kg | 0.5 mg | An additional 0.5 mg from a new device |
| Children 2 to under 12 years, 45 kg or more | 1 mg | An additional 1 mg from a new device |
| Area being examined | IV dose |
|---|---|
| Stomach, duodenal bulb, duodenum and small bowel | 0.2 mg to 0.5 mg |
| Colon | 0.5 mg to 0.75 mg |
Given by a healthcare provider, diluted, as a 1-minute slow IV push. Not a rescue dose.
Emergency help is called immediately after the dose is given.
Once the person has responded, they are given carbohydrates by mouth to restore liver glycogen and prevent low blood sugar coming back.
The solution should be clear and colorless to pale yellow. The HypoPen and PFS stay in their foil pouch, and the Kit in its carton, until ready to use.
Gvoke is stored at 68 F to 77 F (20 C to 25 C), with brief excursions between 59 F and 86 F allowed. It is not refrigerated or frozen.
The Gvoke label has no missed-dose rule because Gvoke is not taken on a schedule; it is a single rescue dose used when severe low blood sugar happens. The label's only repeat-dose rule is that if there is no response after 15 minutes, another dose from a new device may be given while waiting for emergency help (section 2.1).
In Dose Track you set up Gvoke as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.
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