White kidney bean extract (Phaseolus vulgaris) is sold as a "carb blocker" because in the lab it blocks alpha-amylase, an enzyme that breaks down starch. Trials of it for weight loss have mixed results: a 2011 review found it lowered body fat a little but did not change body weight overall.
Also known as: Phaseolus vulgaris, Phase 2, starch blocker, carb blocker.
Trials used about 445 mg once a day before a carbohydrate-rich meal, 1,500 mg twice a day with meals, and 1,000 mg three times a day before meals (ODS). The 2011 review covered 445 to 1,500 mg a day for 4 to 13 weeks. These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling. How it differs from GLP-1 medicines: semaglutide (Wegovy) and tirzepatide (Zepbound) are prescription drugs whose FDA labels include reducing excess body weight and keeping it off long term in adults with obesity, or with overweight and a weight-related condition, alongside diet and exercise. White kidney bean extract is not an FDA-approved drug for weight loss.
What studies show: a 2011 meta-analysis of 6 trials (247 people) found about 1.86 kg more body fat loss than placebo but no significant difference in body weight, and said all the trials had serious design flaws (Onakpoya 2011). In an 8-week US trial in adults with obesity, 1,500 mg twice a day did not lead to significantly more weight loss than placebo (Udani 2004). After that review, a 12-week trial in 123 adults on a mildly reduced-calorie diet found 2.91 kg of weight loss with the extract IQP-PV-101 (3,000 mg a day) versus 0.92 kg with placebo (Grube 2014). ODS calls the results inconsistent.
Safety: ODS lists headaches, soft stools, flatulence and constipation, and no serious side effects in trials, but no trial lasted longer than 13 weeks. FDA warns that many products sold for weight loss, including supplements and teas, are likely to contain dangerous hidden drug ingredients, and that its public list of such products covers only a small fraction of them.
White kidney bean extract is meant to act in the gut on starch digestion (ODS), and we could not find a published half-life or time to peak, so we do not list one.
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