White mulberry leaf extract is a plant extract sold as a supplement to blunt the rise in blood sugar after carbohydrate-rich food. One branded extract, Reducose, is thought to work by reducing how much glucose is absorbed from the gut (Lown 2017).
Also known as: mulberry leaf extract, Reducose.
White mulberry leaf has no intake value. The studies below gave the extract once, together with a sugar or starch drink, in healthy adults. These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
In a crossover study of 37 healthy adults given 50 g of maltodextrin (Lown 2017), the standard dose of mulberry leaf extract cut the rise in blood sugar by 14% and a double dose by 22% compared with placebo, while a half dose had no clear effect; insulin rises fell by about 24%. Stomach and gut symptoms were no different from placebo. In a second study of 38 healthy adults given 75 g of sugar (Thondre 2021), the extract lowered the blood sugar rise by 42% and the insulin rise by 40%, with no reported side effects.
Both were short, single-meal tests in healthy people, and an employee of the extract's maker took part in each study. They do not show long-term effects on diabetes or weight.
We could not find a published half-life or time to peak for white mulberry leaf extract that we could cite, so we do not list one.
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