Testopel (Endo) is crystalline testosterone pressed into small pellets that are implanted under the skin, where they release testosterone slowly for months. It is used for men with low testosterone from testicular or pituitary causes, and for selected boys with clearly delayed puberty.
Also known as: Testopel, testosterone implant.
Each Testopel pellet holds 75 mg of testosterone and is about 3.2 mm across and 9 mm long. Pellets come one per vial, in boxes of 10 or 100.
The Testopel label approves it as testosterone replacement in men with low or absent testosterone from primary hypogonadism (testicular failure) or hypogonadotropic hypogonadism, and to start puberty in carefully selected boys with clearly delayed puberty. The label says safety and effectiveness in age-related ("late-onset") hypogonadism have not been established. Its dose guideline is 150 to 450 mg (two to six pellets) implanted under the skin every 3 to 6 months, sized at two 75 mg pellets for each 25 mg of testosterone propionate a week by injection; the effect usually lasts 3 to 4 months, sometimes 6. The diagnosis is first confirmed by two low morning testosterone results.
The label has no boxed warning. It is not used with breast cancer or known or suspected prostate cancer, and it can harm a female fetus. Warnings cover infection and pellets pushing out at the implant site (mostly in the first month), blood clots, heart risk and blood pressure, liver and prostate effects, and abuse. Because pellets release over months, the dose is hard to adjust once implanted. The label lists side effects without percentages. Full details are on the Testopel side effects and Testopel dosing schedule pages, and Testopel vs testosterone cypionate compares pellets with shots.
The Testopel label does not give a half-life or time to peak. It says the pellets slowly release testosterone for a long-acting effect that usually lasts three to four months and sometimes up to six, so we do not list a number.
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