Mesterolone (Proviron): US Status, WADA and Studies
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Mesterolone: US status, WADA and studies

US status · Approval status · Half-life notes

What is mesterolone?

Mesterolone is an oral synthetic androgen, chemically 1α-methyl-5α-androstan-17β-ol-3-one, a methylated form of dihydrotestosterone (DHT). It was made by Schering and sold as Proviron, and it was studied in the 1980s as a treatment for male infertility. We found no mesterolone product approved in the US.

Also known as: Proviron, 1α-methyl-DHT.

US products

We found no mesterolone product in FDA's Drugs@FDA database, so there are no US label strengths to list. The infertility trials below used 75 mg and 150 mg a day. These are study protocols, not a recommendation.

Approval status and how it is used

Mesterolone has no FDA label for people that we could find. It is a Schedule III controlled substance in the US: the federal list of anabolic steroids names it as mesterolone (1α-methyl-17β-hydroxy-5α-androstan-3-one) in 21 CFR 1308.13(f)(45), so having it without a valid prescription is illegal. WADA lists it among anabolic androgenic steroids (S1.1), banned in sport at all times.

In a World Health Organization trial at 7 centres (1989), 248 infertile couples were randomized to 75 mg or 150 mg of mesterolone a day or placebo for the man for 6 months. Pregnancy rates 8 months later were 9% on placebo, 12% on 75 mg and 16% on 150 mg, differences too uncertain to show a benefit, and semen quality did not change apart from a rise in sperm count at 3 months that was largest on placebo. In a 12-month trial of 52 men (Gerris 1991), pregnancy rates were 26% on 150 mg a day versus 48% on placebo; the authors said this cast doubt on its use for infertility.

Published case reports describe liver injury caused by mesterolone (2019) and mania in a person with no prior mental illness (2012).

Mesterolone half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We found no published human study giving mesterolone's half-life or time to peak that we could cite, so we do not list one.

How to track mesterolone in Dose Track

  1. Add mesterolone as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each tablet when you take it, including split or fractional tablets, so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Dihydrotestosterone (DHT, Androstanolone)DHT, androstanolone DrostanoloneMasteron, Masterone Methenolone EnanthateMetenolone, Primobolan Clomiphene CitrateClomid

Frequently asked questions

What is the half-life of mesterolone?+
We found no published human study giving mesterolone's half-life or time to peak that we could cite, so we do not list one.
Is mesterolone FDA approved?+
We found no mesterolone product in FDA's Drugs@FDA database. WADA bans it in sport at all times as an anabolic androgenic steroid.
Is mesterolone a controlled substance?+
Yes. Mesterolone is named in the federal Schedule III list of anabolic steroids (21 CFR 1308.13(f)(45)), so having it without a valid prescription is illegal in the US.
Does mesterolone help male infertility?+
The trials did not show it. In a WHO trial of 248 couples, pregnancy rates on 75 mg or 150 mg a day were not clearly better than placebo, and in a 12-month trial pregnancy rates were 26% on mesterolone versus 48% on placebo.
Can I track mesterolone in Dose Track?+
Yes. Mesterolone is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each tablet next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. WHO Task Force on the Diagnosis and Treatment of Infertility. Mesterolone and idiopathic male infertility: a double-blind study. Int J Androl. 1989;12(4):254-264.
  2. Gerris J, et al. Placebo-controlled trial of high-dose mesterolone treatment of idiopathic male infertility. Fertil Steril. 1991;55(3):603-607.
  3. Dudkiewicz J, et al. [Usefulness of mesterolone (Proviron-Schering)]. Ginekol Pol. 1983;54(7):497-501.
  4. Pérez Palacios D, et al. Drug-induced liver injury due to mesterolone: a case report. Gastroenterol Hepatol. 2019;42(10):629-630.
  5. Gahr M, et al. Mania related to mesterolone in a previously mentally healthy person. J Clin Psychopharmacol. 2012;32(5):734-735.
  6. 21 CFR 1308.13(f)(45): Schedule III anabolic steroids, mesterolone (1α-methyl-17β-hydroxy-5α-androstan-3-one). eCFR, October 2026.
  7. World Anti-Doping Agency. 2026 Prohibited List (S1.1 anabolic androgenic steroids; S3 beta-2 agonists; S6 stimulants and the 2026 Monitoring Program).

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