Short answer: Calcitonin salmon has a half-life of about 1 hour (injection); about 18 minutes (nasal). Levels peak about 23 minutes (injection); about 13 minutes (nasal) after a dose. People vary, so treat these as estimates.
Calcitonin salmon is a lab-made version of calcitonin, the salmon form of a hormone that slows bone breakdown (resorption) and lowers blood calcium. It is sold as Miacalcin injection for Paget's disease of bone, high blood calcium and postmenopausal osteoporosis, and as a nasal spray for postmenopausal osteoporosis.
Also known as: Miacalcin, calcitonin.
Miacalcin injection is 200 USP Units/mL in a 2 mL multiple-dose vial, injected under the skin or into muscle. Calcitonin salmon nasal spray gives 200 International Units per spray.
The Miacalcin injection label approves it for symptomatic Paget's disease of bone (100 Units a day), for early treatment of dangerously high blood calcium (4 Units/kg every 12 hours, up to 8 Units/kg every 6 hours), and for osteoporosis in women more than 5 years past menopause (100 Units a day) when other treatments are not suitable. The nasal spray label approves one spray (200 Units) a day, alternating nostrils, for the same osteoporosis use. Both say reductions in fractures have not been shown.
The labels warn that in a meta-analysis of 21 trials, cancers were more common with calcitonin salmon than placebo (4.1% versus 2.9%), so continued use should be re-checked periodically. They also warn about serious allergic reactions, low blood calcium with muscle cramps or seizures (calcium must be normal before starting), and antibodies; the spray can cause nose ulcers. See also teriparatide.
The Miacalcin label gives a terminal half-life of about 58 minutes after an injection into muscle and 59 to 64 minutes under the skin, with peak levels about 23 minutes after an injection under the skin. The nasal spray label gives a peak at about 13 minutes and a half-life of about 18 minutes; the spray delivers only 3% to 5% as much as a muscle injection.
Numbers shown are taken from the source above. Half-life varies from person to person.
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