Jentadueto vs Janumet: Two DPP-4 Plus Metformin Tablets
App Library Tools Pricing Download
[Type 2 diabetes · DPP-4 · Comparison]

Jentadueto vs Janumet: how do the two DPP-4 and metformin tablets differ?

What is in it · Dose · Kidney limits · Side effects

Short answer: Both pair a DPP-4 inhibitor with metformin, are taken twice daily with meals, and carry a boxed warning for lactic acidosis.12 Jentadueto uses linagliptin, 2.5 mg per tablet; Janumet uses sitagliptin, 50 mg per tablet. Both are for adults, are not used below an eGFR of 30, and have limits from 30 to 45. Neither label reports a trial against the other.

How do Jentadueto and Janumet compare side by side?

From the US Jentadueto and Janumet labels. Each side-effect row comes from that label's own 24-week trial of the two drugs started together.
JentaduetoJanumet
Paired with metforminLinagliptin 2.5 mg per tablet1Sitagliptin 50 mg per tablet2
How takenTwice daily with meals1Twice daily with meals; tablets not split2
Start without metformin2.5 mg/500 mg twice daily150 mg/500 mg twice daily2
Maximum2.5 mg/1,000 mg twice daily1Sitagliptin 100 mg and metformin 2,000 mg a day2
Kidney limitsNot used with an eGFR below 30; starting at 30 to 45 not recommended1Not used with an eGFR below 30; not recommended at 30 to under 452
Side effects, started togetherStuffy or runny nose 6.3% vs 1.4% on placebo; diarrhea 6.3% vs 2.8%1Diarrhea 7.5% vs 4.0% on placebo; headache 5.9% vs 2.8%2
Missed doseTake with food when remembered; skip if the next dose is due1Take when remembered; skip if the next dose is due2
Boxed warningWARNING: LACTIC ACIDOSIS1WARNING: LACTIC ACIDOSIS2

Reviewed . Half-life figures are shown only where the value Dose Track uses agrees with the cited source.

How do the warnings compare?

Both list lactic acidosis, pancreatitis, low blood sugar with insulin or a sulfonylurea, allergic reactions, lower vitamin B12, severe joint pain, bullous pemphigoid and heart failure seen with two other DPP-4 inhibitors.12 The Janumet label also lists acute kidney failure reported after approval, and says people at an eGFR of 30 to under 45 need a lower sitagliptin dose than the fixed tablet has.2 Both say to stop the tablet for a time while food and fluids are restricted for surgery, without giving a number of days. These numbers come from separate trials with different people, lengths and methods, so they are not a head-to-head comparison.

Which, if either, fits is for your prescriber. More detail: Jentadueto side effects, Janumet side effects, the Jentadueto and Janumet dosing schedules, the Janumet missed-dose page and Januvia vs Tradjenta: how do the two DPP-4 tablets differ?.

Januvia vs Tradjenta: how do the two DPP-4 tablets differ?Kidney-adjusted dose vs one 5 mg dose for all Januvia vs Janumet: what does adding metformin change?Sitagliptin alone vs sitagliptin plus metformin Glyxambi vs Janumet: how do the two diabetes combination tablets differ?Empagliflozin plus linagliptin vs sitagliptin plus metformin

Frequently asked questions

Do both contain metformin?+
Yes. Jentadueto pairs it with linagliptin and Janumet with sitagliptin.12
Are both taken twice a day?+
Yes, with meals. The Jentadueto label does not cover Jentadueto XR, which has its own label.12
What if I miss a dose?+
Both Medication Guides say to take it when you remember, or skip it if the next dose is due, and never take 2 doses at once. Jentadueto's says to take it with food.12
Can Dose Track remind me to take them?+
Yes. You can log each dose and set a reminder.

Sources

  1. Jentadueto (linagliptin and metformin hydrochloride) tablets prescribing information and Medication Guide, boxed warning and sections 1, 2, 5, 6 and 17. DailyMed, version of August 26, 2026.
  2. Janumet (sitagliptin and metformin hydrochloride) tablets prescribing information and Medication Guide, boxed warning and sections 1, 2, 3, 5 and 6. DailyMed, version of August 27, 2026.

All compound comparisons · All compound guides · Peptide tracking in Dose Track