Short answer: Store Premarin Vaginal Cream at room temperature, 68-77°F (20-25°C), with excursions allowed to 59-86°F (15-30°C). The label says nothing about the refrigerator or how long a tube lasts once opened. Clean the applicator with mild soap and warm water; the leaflet says do not boil it or use hot water. Source: Premarin Vaginal Cream label, section 16.2 and Patient Information.
Section 16.2, repeated in the Patient Information: “Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].”
| Question | Label answer |
|---|---|
| Temperature | 68-77°F (20-25°C) |
| Excursions | 59-86°F (15-30°C) |
| Refrigerator | Not stated |
| After opening | Not stated |
| Packaging | 30 g (1.06 oz) tube, 0.625 mg conjugated estrogens per gram, with plastic applicator(s) marked in 0.5 g steps up to 2 g; the carton says 2 applicators enclosed |
| Applicator cleaning | Mild soap and warm water; do not boil or use hot water |
Patient Information, Step 6: “TO CLEANSE: Pull plunger to remove it from barrel. Wash with mild soap and warm water.” It adds, in capitals: “DO NOT BOIL OR USE HOT WATER.”
The leaflet also says latex or rubber condoms, diaphragms and cervical caps may be weakened and fail when they come into contact with the cream. See Premarin Vaginal Cream side effects, the Premarin Vaginal Cream dosing schedule, and the Vagifem, Imvexxy, Estrace Cream and Intrarosa page for other vaginal products.
No ice pack is needed. Keep the tube capped in your carry-on, within 59-86°F (15-30°C), and out of a hot car. Pack a clean applicator with it.