Introduction to Peptides: What They Are and How They Work
[Guide · Getting started]

Introduction to peptides

7 min read · Also in the Dose Track app under Learn · Updated

Short answer: A peptide is a short chain of amino acids. Your body makes hundreds of them, like insulin and oxytocin, and uses them as messages between cells. Most peptides people use are injected under the skin because the gut breaks them down. Much of the research on newer peptides is in animals, so set your expectations and track what you notice.

What a peptide is

Amino acids are single building blocks. Link a few of them together and you get a peptide. Link a lot of them and fold the chain into a 3D shape and you get a protein. The usual cut-off is about 50 amino acids, though it is a convention more than a hard line.

  • Amino acids: single units, like glycine or leucine.
  • Peptides: about 2 to 50 amino acids in a chain.
  • Proteins: longer chains, usually folded into a fixed shape.

Your body already runs on peptides. Insulin, glucagon and oxytocin are all peptides. Many medicines are peptides too, like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). Other peptides, like BPC-157, are sold for research and are not approved as medicines.

How peptides work

Most peptides act as signals. A peptide travels to a cell, fits into a matching receptor on the cell surface, and that sets off a response inside the cell, such as releasing a hormone.

Because a receptor only responds to signals that fit it, a peptide tends to act on one system. That is part of why researchers are interested in them. It does not mean they have no side effects: approved peptide drugs like semaglutide have well-known ones.

How peptides are taken

  • Under the skin (subcutaneous): the most common route. A small needle puts the dose into the fat layer. Semaglutide and tirzepatide pens work this way.
  • Into muscle (intramuscular): less common for peptides.
  • By mouth: rarely works. Stomach acid and enzymes break peptides apart. Even oral semaglutide (Rybelsus), which is built to survive, reaches the blood at about 0.4% to 1% of the dose, per its label. That is why the tablet dose is much larger than the injected one.
  • In the nose: used for a few small peptides, such as Semax and Selank. Absorption varies.

See the sub-Q injection guide for how an injection under the skin is done.

Peptides, steroids and hormones are different things

Anabolic steroids such as testosterone are built from cholesterol, not amino acids. They pass into the cell and act on receptors inside it. Taking testosterone lowers your own production.

Growth hormone (somatropin) injections give the hormone itself.

Growth-hormone-releasing peptides such as ipamorelin or sermorelin ask your own pituitary gland to release growth hormone, so the release still comes in pulses.

Different does not mean safer. Every compound has its own risks, and many peptides have far less human safety data than approved drugs.

The main groups people talk about

Research info, not a recommendation. Amounts, schedules and timing in this section come from studies (often in animals) and from how people commonly use these compounds. Most are not FDA-approved doses. Your dose is a decision for you and your prescriber.
  • Growth hormone secretagogues: ipamorelin, CJC-1295, sermorelin, GHRP-2, GHRP-6, tesamorelin. Tesamorelin (Egrifta) is FDA-approved for one use; the others are mostly research compounds.
  • Repair peptides: BPC-157, TB-500 (thymosin beta-4), GHK-Cu. Most of the BPC-157 evidence comes from animal studies.
  • Metabolic peptides: semaglutide, tirzepatide, liraglutide (approved), and newer ones in trials such as retatrutide.
  • Brain and mood: Semax and Selank, mostly studied in Russia.
  • Longevity: epitalon and thymalin. Evidence in people is thin.

What to expect

Approved peptide drugs have clinical trial data that tells you what to expect and when. Most research peptides do not. Much of what you read online is personal reports, and effects people describe are often slow and hard to feel day to day.

That is why a baseline helps. Write down how you sleep, your weight, your training and any lab results before you start, then log as you go. With records, you can tell what changed instead of guessing.

"Natural" does not mean safe, and more is not better. Many peptides have a narrow useful range, and side effects usually rise with the dose.

Key points

  • A peptide is a short chain of amino acids; many hormones and some medicines are peptides.
  • Most peptides are injected under the skin because the gut breaks them down.
  • Peptides that release growth hormone work through your pituitary; steroids and growth hormone itself act differently.
  • Much peptide research is early or in animals, so track a baseline and log what you notice.

See also: Compound library · Glossary

This guide is general education, not medical advice. Follow your medicine's label and your prescriber.

Compounds in this guide

Frequently asked questions

Can you take peptides by mouth?+
Most peptides are broken down in the gut, so very little reaches the blood. Oral semaglutide (Rybelsus) is a special case built to survive, and even it is absorbed at about 0.4% to 1% of the dose, per its label.
Are peptides the same as steroids?+
No. Steroids like testosterone are made from cholesterol and act inside the cell. Peptides are amino acid chains that act on receptors on the cell surface. Each has its own risks.
Are research peptides approved by the FDA?+
Many are not. Some peptides, such as semaglutide, tirzepatide and tesamorelin, are approved drugs. Others, such as BPC-157, are sold for research and have little human data.