Short answer: The label dose is 1300 mg (two 650 mg tablets) three times a day, 3900 mg a day, for a maximum of 5 days during monthly menstruation, with or without food, swallowed whole. It is taken only once a period has started. Doses are lower when serum creatinine is above 1.4 mg/dL. A missed dose is taken when remembered, with the next dose at least six hours later.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Lysteda is approved for: Tranexamic acid tablets are an antifibrinolytic (a medicine that slows the breakdown of blood clots) approved to treat cyclic heavy menstrual bleeding in females of reproductive potential (section 1). Lysteda has no current brand-name label on DailyMed; this page uses the current label for the same 650 mg product under the Lysteda application (NDA 022430), sold by Nordic Pharma as tranexamic acid tablets.
Source
Tranexamic acid tablets, USP 650 mg (NDA 022430, the Lysteda product), prescribing information. Nordic Pharma. DailyMed, version published November 17, 2025. DailyMed setid 031bf7c2-3b07-469d-bc5a-31fc6238e25f
The tablets are 650 mg, white and oval, debossed "FP650". The dose is two tablets three times a day (for example morning, afternoon and evening) once a period has started (sections 3 and 2.2; Patient Information).
They are swallowed whole, not chewed or broken apart, and may be taken with or without food (section 2.2).
Before prescribing, other causes of heavy bleeding in the lining of the uterus are ruled out (section 2.1). The tablets are taken only during menstruation and for no more than 5 days each month (section 17).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Serum Creatinine (mg/dL) | Recommended Dosage | Total Daily Dose |
|---|---|---|
| Normal renal function | 1300 mg three times daily | 3900 mg |
| Above 1.4 and ≤ 2.8 | 1300 mg two times a day | 2600 mg |
| Above 2.8 and ≤ 5.7 | 1300 mg once a day | 1300 mg |
| Above 5.7 | 650 mg once a day | 650 mg |
All doses are for a maximum of 5 days during menstruation. Serum creatinine is a blood test of kidney function.
Not more than 6 tablets a day. Not taken before the period starts, when there is no period, or for more than 5 days in a row.
No dose change is needed for liver impairment, because only a small fraction of the drug is metabolized.
Not indicated before the first period or for postmenopausal women.
Peak levels come about 3 hours after a 1300 mg dose, and steady state is reached at the 5th dose on day 2. Taking it with food raised peak level 7% and exposure 16%.
Tranexamic acid is stopped if a tissue plasminogen activator (a clot-dissolving medicine) is needed.
Stored at 25 C (77 F), with excursions from 15 to 30 C (59 to 86 F) allowed.
If you miss a dose, take it when you remember, and then take your next dose at least six hours later. Do not take more than two tablets at a time to make up for missed doses.
More on this: missed a dose of Lysteda.
In Dose Track you set up Lysteda as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.