Short answer: The diethylpropion 25 mg label dose is one tablet three times daily, one hour before meals, and in midevening if desired to overcome night hunger. It is for short-term use of a few weeks, and continues only with satisfactory weight loss in the first 4 weeks. If tolerance develops, the dose is not raised; the drug is stopped. The label gives no missed-dose instruction.
This is what the FDA label says. Follow your prescriber. Your prescriber may use a different dose or pace than the label's standard schedule.
What Diethylpropion is approved for: Diethylpropion is approved as a short-term (a few weeks) add-on to a calorie-restricted weight-loss plan for obesity in people with a starting BMI of 30 kg/m2 or more who have not responded to diet and/or exercise alone (Indications and Usage). The label says diethylpropion tablets are schedule IV controlled substances (Drug Abuse and Dependence).
Source
Diethylpropion Hydrochloride Tablets USP, 25 mg, CIV, prescribing information. PD-Rx Pharmaceuticals (repackager). DailyMed, version published October 19, 2026. DailyMed setid 5777eed8-c63d-49c4-9dd1-9d087906c368
Diethylpropion 25 mg is a tablet taken by mouth, one tablet three times daily, one hour before meals (Dosage and Administration).
A midevening tablet may be added if desired to overcome night hunger (Dosage and Administration).
It is a short-term add-on of a few weeks to a calorie-restricted weight-loss plan (Indications and Usage).
The table below is the label's schedule, from the Dosage and Administration section. Numbers are copied exactly; the section is in brackets.
| Timing | Dose |
|---|---|
| Three times daily, one hour before meals | One 25 mg tablet each time |
| Midevening, if desired to overcome night hunger | One 25 mg tablet |
Treatment continues only if there is satisfactory weight loss within the first 4 weeks, for example at least 4 pounds, or as decided by the physician and patient.
If tolerance develops, the recommended dose is not exceeded to increase the effect; the drug is stopped instead.
Diethylpropion is mostly cleared by the kidneys, so dose selection in older people is careful and kidney function may be monitored.
The least amount feasible is prescribed or dispensed at one time to reduce the chance of overdose. It is not recommended for people 16 and under.
Tablets are kept tightly closed and stored at 20 to 25 C (68 to 77 F).
The diethylpropion label gives no missed-dose instruction. Ask your prescriber or pharmacist what to do if a dose is missed.
In Dose Track you set up Diethylpropion as a protocol with the dose and schedule your prescriber gave you. A protocol can hold dose steps, each with its own dose and length in days or weeks, so a step-up plan like the one on the label can be entered once and the app moves to the next step on its own. Reminders follow the schedule, and every dose is logged with the date and time, so you can see which step you are on and when your last dose was. The app follows what you enter; it does not choose or change a dose.
This page is what the FDA label says, in plain words. It is not medical advice. Follow your prescriber, and ask them or your pharmacist about anything here.