Schisandra: Small Trials and Tacrolimus Interaction
[Supplement · Compound guide]

Schisandra: half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is schisandra?

Schisandra (Schisandra chinensis, omija in Korea) is a plant whose berries are used in traditional Chinese and Korean medicine. As a supplement it has been studied for menopause symptoms and muscle strength in older adults.

Also known as: Schisandra chinensis, omija.

Amounts studied

A 12-week trial in older adults used 1 g of extract a day (Cho 2021). A menopause trial used an extract called BMO-30 for 6 weeks (Park 2016). These are study protocols, not a recommendation.

Approval status and how it is used

It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.

What studies show: in a trial of 54 adults over 50 who walked regularly, 12 weeks of schisandra extract increased knee strength more than placebo but did not change muscle mass, and no one had side effects (Cho 2021). In a trial of 36 women with menopause symptoms, a schisandra extract lowered symptom scores more than placebo over 12 weeks, especially hot flushes, sweating and palpitations (Park 2016). Both trials were small.

Drug interaction: a 2021 review lists schisandra among herbs that raised blood levels of tacrolimus, a transplant drug with a narrow safe range, in human and/or animal studies, by blocking CYP3A enzymes and the P-glycoprotein pump. The review says people taking tacrolimus should be told about these herb interactions.

Schisandra half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for schisandra that applies to a supplement dose, so we do not list one. Herbal products are mixtures of many plant compounds, so no single figure would describe them.

How to track schisandra in Dose Track

  1. Add schisandra as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Frequently asked questions

What is the half-life of schisandra?+
We could not find a single published half-life or time to peak for schisandra that applies to a supplement dose, so we do not list one. Herbal products are mixtures of many plant compounds, so no single figure would describe them.
Does schisandra interact with medicines?+
It can. A 2021 review found schisandra raised blood levels of tacrolimus, a transplant drug with a narrow safe range, in human and/or animal studies by blocking the enzymes and pump that clear it.
Does schisandra help muscle strength?+
One trial of 54 older adults found 12 weeks of extract improved knee strength but not muscle mass compared with placebo. That is a single small trial.
Can I track schisandra in Dose Track?+
Yes. Schisandra is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.