Eleuthero (Eleutherococcus senticosus), sold as Siberian or Russian ginseng, is a plant used in traditional Chinese medicine to combat fatigue and strengthen the immune system; it is not related to Panax (true) ginseng. As a supplement it is taken as an "adaptogen" for stamina, fatigue and stress.
Also known as: Siberian ginseng, Eleutherococcus senticosus, Acanthopanax senticosus, Russian ginseng.
A small trial ODS describes used 800 mg a day of root and rhizome extract for 8 weeks. Many Soviet-era studies used 2 mL of liquid extract a day (Gerontakos 2021). These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: per the NIH Office of Dietary Supplements, a review of the five most rigorous endurance studies (79 people) found no effect for up to 6 weeks, while a later trial of nine college tennis players found better cycling endurance after 8 weeks. A 2021 review translated 46 trials published in the USSR between 1962 and 1986, mostly in healthy volunteers, which reported benefits for physical and mental stamina and fewer colds and flu; the reviewers say the findings should be read within their limits. The review notes that the European Medicines Agency recognizes it for symptoms of weakness and fatigue.
Safety, per ODS: short-term use appears safe; the studies above reported no side effects, though other trials list insomnia as a rare side effect.
We could not find a single published half-life or time to peak for eleuthero that applies to a supplement dose, so we do not list one. Herbal products are mixtures of many plant compounds, so no single figure would describe them.
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