Pueraria mirifica is a Thai plant rich in plant estrogens (phytoestrogens), used traditionally as a rejuvenating remedy after menopause and sold for menopause symptoms. A 2018 systematic review found its effect on menopause symptoms inconclusive.
Also known as: kwao krua khao, white kwao krua, Pueraria candollei var. mirifica.
A Thai trial gave 20, 30 or 50 mg a day for 24 weeks (Manonai 2008). These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: a 2018 review of 8 studies (309 women) found menopause symptom scores fell by about half from baseline, but the studies had high risk of bias, used undefined products and few placebo participants, so the reviewers called the efficacy inconclusive (Kongkaew 2018). In a 24-week trial in 71 postmenopausal women, it lowered a marker of bone turnover, an estrogen-like effect, but did not thicken or change the womb lining (Manonai 2008).
Safety: side effects such as breast tenderness, vaginal spotting and dizziness were similar to placebo and estrogen cream, but C-reactive protein, an inflammation marker, doubled (Kongkaew 2018). The 24-week trial found no differences from placebo in breast scans, blood counts, or liver and kidney tests (Manonai 2008). Both sources call for better studies of its long-term safety.
We could not find a single published half-life or time to peak for Pueraria mirifica that applies to a supplement dose, so we do not list one. Plant extracts are mixtures of many compounds, so no single figure would describe them.
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