Red clover is a legume that contains isoflavones, plant compounds similar in structure to estrogen. As a supplement it is promoted for women's health, mainly menopause hot flashes.
Also known as: Trifolium pratense, red clover isoflavones.
A 12-month trial described by ODS used 398 mg a day of red clover extract standardized to 120 mg of isoflavones. These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show, per NCCIH: research has not shown clear benefits for any condition. Studies on hot flashes have had inconsistent results, some with high risk of bias; it may help cholesterol in postmenopausal women but more research is needed; and the few bone density studies are inconsistent. In a 12-month trial of 88 women described by the NIH Office of Dietary Supplements, red clover was no better than placebo for hot flashes and night sweats.
Safety, per NCCIH: red clover extracts have been used in studies for up to 2 years with apparent safety and seem well tolerated. They may be unsafe during pregnancy or breastfeeding.
We could not find a single published half-life or time to peak for red clover that applies to a supplement dose, so we do not list one. Herbal products are mixtures of many plant compounds, so no single figure would describe them.
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