Progesterone is a female sex hormone made by the ovaries. Prometrium is micronized progesterone in capsules, chemically identical to the body's own. The FDA label approves it to protect the uterine lining in women taking estrogen after menopause and to bring back periods that have stopped.
Also known as: Prometrium.
Prometrium and its generics come as 100 mg and 200 mg capsules. The capsules contain peanut oil.
The FDA Prometrium label approves it to prevent overgrowth of the uterine lining (endometrial hyperplasia) in postmenopausal women with a uterus who take conjugated estrogens tablets, at 200 mg once a day at bedtime for 12 days of each 28-day cycle. For periods that have stopped (secondary amenorrhea) the label dose is 400 mg at bedtime for 10 days.
It is taken at bedtime because it can cause dizziness and drowsiness; a few women have had extreme dizziness, blurred vision or trouble walking when starting. It is not used by people allergic to peanuts, or with breast cancer, unexplained vaginal bleeding, liver disease, or a current or past blood clot, stroke or heart attack. See the Prometrium side effects page for the label's numbers.
The FDA Prometrium label says peak levels are reached within 3 hours of an oral capsule; in its table of postmenopausal women, mean time to peak was 1.5 to 2.3 hours at 100 to 300 mg a day. Taking it with food raised how much was absorbed. The label does not give a half-life for oral progesterone, so we do not list one.
Numbers shown are taken from the source above. Half-life varies from person to person.
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