Pomegranate (Punica granatum) is a fruit whose juice and extracts are sold for blood pressure, heart health and diabetes. NCCIH says juice or extract may lower blood pressure and blood sugar a little, but many studies used juice rather than supplements.
Also known as: pomegranate, Punica granatum, punicalagins, pomegranate juice.
The meta-analyses below pooled juices, extracts and other forms in different amounts, so we do not list one.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: a 2024 meta-analysis of 22 trials found pomegranate lowered systolic blood pressure by about 7.9 mmHg and diastolic by about 3.2 mmHg, more in people starting above 130 mmHg, though results varied widely (Bahari 2024, blood pressure). A 2024 meta-analysis of 32 trials found small drops in fasting blood sugar (about 2.2 mg/dL), insulin and HbA1c (about 0.2 percentage points) (Bahari 2024, glycemic). NCCIH says no clear effect on cholesterol has been shown, and the evidence is too limited for other conditions.
Safety, per NCCIH: juice is believed to be safe and extract may also be safe. The root, stem and peel may not be safe in large amounts. Side effects are uncommon, mostly digestive, and allergic reactions have been reported. Little is known about forms other than juice in pregnancy or breastfeeding.
We could not find a single published half-life or time to peak for pomegranate extract that applies to a supplement dose, so we do not list one. Plant extracts are mixtures of many compounds, so no single figure would describe them.
How Dose Track handles peptides · Reconstitution calculator · Half-life calculator