Palmitoyl tetrapeptide-7 (Pal-GQPR) is a lab-made four-amino-acid peptide with a fatty acid attached, used in anti-aging skin care. It is one of the two peptides in Matrixyl 3000, with palmitoyl tripeptide-1, and is also used in products for sensitive skin. It has only been tested in people as part of blends.
Also known as: Pal-GQPR, Matrixyl 3000 (with palmitoyl tripeptide-1).
There is no standard strength, and the studies below do not give a concentration in the abstract.
Skin-care peptides are sold as cosmetic ingredients. FDA does not approve cosmetics before they go on the market. FDA says a product that only moisturizes so lines look less noticeable is a cosmetic, but a product intended to remove wrinkles or increase the skin's production of collagen is a drug or a medical device, even if it is sold as a cosmetic.
A study mostly by researchers at the company Sederma (Mondon 2015) applied a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 and used skin imaging; the blend improved the structure of the deeper skin layer compared with placebo, in what the authors called a preliminary study. A 12-week study of an eye cream led by a company research center (Yang 2024) reported better skin moisture, elasticity and fine lines, but the cream had four active ingredients, including both Matrixyl 3000 peptides. In three women (Trzaska 2026), both Matrixyl 3000 peptides were found throughout the outer skin layer, between the cells rather than inside them.
A 2021 review of peptides in sensitive-skin products (Resende) found palmitoyl tetrapeptide-7 among them, and said the evidence for these peptides is mostly in patents and supplier brochures, not randomized placebo-controlled studies.
We could not find a published half-life or time to peak for palmitoyl tetrapeptide-7. It is applied to the skin, and the studies we found measured the skin, not levels in the blood, so we do not list one.
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