Oxaloacetate: Alzheimer's and Fatigue Studies | Dose Track
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Oxaloacetate: half-life, strengths and approval status

Amounts studied · Approval status · Half-life notes

What is oxaloacetate?

Oxaloacetate is a molecule in the body's main energy cycle (the Krebs cycle) and in glucose production. It is sold as a supplement, and early studies have tested it in Alzheimer's disease and chronic fatigue.

Also known as: OAA, anhydrous enol-oxaloacetate, oxaloacetic acid.

Amounts studied

Alzheimer's studies used 100 mg twice a day, then 500 or 1,000 mg twice a day, for 1 month (Swerdlow 2016, Vidoni 2021). A fatigue study used 500 mg twice a day up to 1,000 mg three times a day for 6 weeks (Cash 2022). These are study protocols, not a recommendation.

Approval status and how it is used

The NIH Dietary Supplement Label Database lists oxaloacetate products labeled as dietary supplements, such as Mitachrome OAA. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.

What studies show: in 6 people with Alzheimer's disease, 100 mg twice a day for a month was well tolerated but did not clearly raise blood levels (Swerdlow 2016). In 30 people with Alzheimer's, 500 or 1,000 mg twice a day for a month were safe; the higher dose increased brain glucose uptake on PET scans, but blood levels did not change consistently and thinking scores did not improve (Vidoni 2021). In a non-randomized, open-label study in people with ME/CFS or long-COVID fatigue, fatigue scores fell 22.5% to 27.9% in ME/CFS over 6 weeks, compared with a historical placebo group; it was funded by Terra Biological, and the first author is an officer of that company (Cash 2022).

Safety: both Alzheimer's studies found the doses tested safe and well tolerated over 1 month. The sources here do not describe drug interactions.

Oxaloacetate half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for oxaloacetate that applies to a supplement dose, so we do not list one. In the Alzheimer's studies, blood oxaloacetate did not rise consistently after doses, partly because the body already has relatively high natural levels (Swerdlow 2016, Vidoni 2021).

How to track oxaloacetate in Dose Track

  1. Add oxaloacetate as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

Oral NAD+ Precursors (NR and NMN)nicotinamide riboside, NR Creatine Monohydratecreatine monohydrate Coenzyme Q10 (CoQ10)coenzyme Q10, ubiquinone · half-life about 33 hours

Frequently asked questions

What is the half-life of oxaloacetate?+
We could not find a single published half-life or time to peak for oxaloacetate that applies to a supplement dose, so we do not list one. In the Alzheimer's studies, blood oxaloacetate did not rise consistently after doses, partly because the body already has relatively high natural levels (Swerdlow 2016, Vidoni 2021).
Does oxaloacetate help Alzheimer's disease?+
It has not been shown to. In a 1-month study in 30 people with Alzheimer's, the higher dose changed brain energy use on scans, but thinking scores did not improve.
Can I track oxaloacetate in Dose Track?+
Yes. Oxaloacetate is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Swerdlow RH, et al. Tolerability and pharmacokinetics of oxaloacetate 100 mg capsules in Alzheimer's subjects. BBA Clin. 2016;5:120-123.
  2. Vidoni ED, et al. Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimers Dement. 2021;17(1):7-17.
  3. Cash A, Kaufman DL. Oxaloacetate treatment for mental and physical fatigue in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long-COVID fatigue patients: a non-randomized controlled clinical trial. J Transl Med. 2022.
  4. FDA. Questions and answers on dietary supplements.
  5. NIH ODS Dietary Supplement Label Database. OAA (Mitachrome), oxaloacetate dietary supplement label, entered July 21, 2022; checked October 28, 2026.

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