Short answer: CoQ10 has a half-life of about 33 hours. Levels peak about 6 hours after a dose. People vary, so treat these as estimates.
Coenzyme Q10 (CoQ10) is a substance the body makes, with the highest levels in the heart, liver, kidneys and pancreas. It helps the mitochondria make energy and acts as an antioxidant. As a supplement it has been studied for heart conditions, statin muscle pain and other uses.
Also known as: coenzyme Q10, ubiquinone, ubiquinol.
CoQ10 has no intake value or upper limit. ODS reports no safety concerns with up to 900 mg a day for 4 weeks in healthy people, and 600 to 3,000 mg a day in studies of people with Huntington's or Parkinson's disease. These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling. There is no FDA-approved CoQ10 drug.
NCCIH says the overall evidence does not support CoQ10 for statin muscle pain, it probably has no meaningful effect on blood pressure, and research on heart failure and heart disease prevention is inconclusive, though it may reduce some complications of heart surgery. No serious side effects have been reported; mild ones include insomnia and digestive upset. CoQ10 may interact with the blood thinner warfarin and with insulin, and may not be compatible with some cancer treatments.
A review of CoQ10 pharmacokinetics (Bhagavan and Chopra 2006) gives a time to peak of about 6 hours and an elimination half-life of about 33 hours. Absorption is slow and limited because CoQ10 is a large, fat-soluble molecule; solubilized formulations are absorbed better.
Numbers shown are taken from the source above. Half-life varies from person to person.
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