Methylliberine (Dynamine): Studies and Safety | Dose Track
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Methylliberine: What studies show

Amounts studied · Approval status · Half-life notes

What is methylliberine?

Methylliberine is a purine alkaloid, related to caffeine and theacrine, found in a type of coffee plant (Coffea liberica). It has been studied as the branded ingredient Dynamine.

Also known as: Dynamine, methyliberine, 1,7,9-trimethyluric acid.

Amounts studied

Studies used 100 or 150 mg a day for 4 weeks (VanDusseldorp 2020), 100 mg a day for 4 days (La Monica 2023), and 100 mg with 150 mg caffeine and 50 mg theacrine as a single dose (Cintineo 2022). These are study protocols, not a recommendation.

Approval status and how it is used

Methylliberine is studied as a caffeine alternative. It is not an approved drug, and we found no FDA statement on its use in supplements.

What studies show: in 25 healthy adults, 100 mg a day improved self-rated energy, concentration, motivation and mood over 3 hours compared with placebo, but did not improve scores on thinking tests (La Monica 2023). In 48 tactical personnel, a single dose of methylliberine with 150 mg caffeine and 50 mg theacrine improved reaction time on a vigilance task about as much as 300 mg of caffeine, with no rise in diastolic blood pressure over placebo (Cintineo 2022).

Safety: in 125 young adults, 4 weeks of 100 or 150 mg a day, with or without theacrine, caused no clinically significant changes in heart, blood pressure or blood tests (VanDusseldorp 2020). Combined with caffeine, systolic blood pressure was higher than placebo (Cintineo 2022). Most of these trials tested the branded ingredient, and the sources here do not describe drug interactions.

Methylliberine half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed

We could not find a single published half-life or time to peak for methylliberine that applies to a supplement dose, so we do not list one. A 2020 study measured it in blood after 100 mg with caffeine and theacrine, but its abstract does not give the values.

How to track methylliberine in Dose Track

  1. Add methylliberine as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

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TheacrineTeaCrine Caffeinecaffeine anhydrous L-Theaninetheanine GuaranaPaullinia cupana

Frequently asked questions

What is the half-life of methylliberine?+
We could not find a single published half-life or time to peak for methylliberine that applies to a supplement dose, so we do not list one. A 2020 study measured it in blood after 100 mg with caffeine and theacrine, but its abstract does not give the values.
Is methylliberine like caffeine?+
It is a related compound. In one trial it improved self-rated energy and mood but not test scores. Combined with caffeine and theacrine, it matched double the caffeine for reaction time in another trial.
Can I track methylliberine in Dose Track?+
Yes. Methylliberine is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. VanDusseldorp TA, et al. Safety of short-term supplementation with methylliberine (Dynamine) alone and in combination with TeaCrine in young adults. Nutrients. 2020;12(3):654.
  2. La Monica MB, et al. Methylliberine ingestion improves various indices of affect but not cognitive function in healthy men and women. Nutrients. 2023;15(21):4509.
  3. Cintineo HP, et al. Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2022;19(1):543-564.

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