Theacrine is a purine alkaloid, chemically related to caffeine. It is sold, often as TeaCrine, as a supplement for energy, focus and mood, and it is often combined with caffeine.
Also known as: TeaCrine.
Studies used 25 or 125 mg (He 2017), up to 400 mg (Gardiner 2024), and 3 or 6 mg per kg of body weight (Vieira-Cavalcante 2025). These are study protocols, not a recommendation.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: in 8 healthy adults, taking caffeine with theacrine raised theacrine blood levels, and neither changed heart rate or blood pressure; this study was funded by Compound Solutions, Inc., and it cites an earlier study reporting more energy and focus (He 2017). In a sleep study, 400 mg of theacrine taken within 8 hours of bedtime reduced lapses of attention the next morning but did not improve reaction time, and had no significant effect on sleep (Gardiner 2024). In 19 cyclists, 3 or 6 mg per kg did not improve 4 km time-trial performance (Vieira-Cavalcante 2025). These are small studies.
Safety: in the cycling study, 6 mg per kg raised resting blood pressure, and people reported stomach discomfort, a feeling of fast heartbeat, dizziness, headache, head pressure and hand tremor after either dose (Vieira-Cavalcante 2025). Caffeine raises theacrine levels when taken together (He 2017).
One small study in 8 adults measured theacrine blood levels over 24 hours: caffeine raised peak theacrine levels and total exposure without changing its half-life (He 2017). We could not confirm a single half-life or time to peak from the published abstract, so we do not list one.
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