Short answer: Ibandronate has a half-life of 37 to 157 hours (150 mg tablet). Levels peak 0.5 to 2 hours (median 1 hour) after a dose. People vary, so treat these as estimates.
Ibandronate is a bisphosphonate, a drug that binds to bone and slows the cells that break bone down. The tablet is sold as Boniva and as generic ibandronate sodium tablets, taken once a month for osteoporosis in women after menopause.
Also known as: Boniva, ibandronate sodium.
Generic ibandronate tablets come as 150 mg, taken once a month on the same date.
The ibandronate tablet label approves it to treat and prevent osteoporosis in women after menopause. Label dosing is one 150 mg tablet once a month on the same date. It is swallowed whole with 6 to 8 ounces of plain water at least 60 minutes before the first food, drink or other medicine of the day, while sitting or standing upright, and the person does not lie down for 60 minutes. Mineral water, coffee, tea, soda and juice are avoided with the dose. A missed dose is taken the next morning if the next one is more than 7 days away. The best length of use is not known, and people at low fracture risk may be considered for stopping after 3 to 5 years.
The label has no boxed warning. Warnings cover irritation and ulcers of the esophagus, low calcium, jaw bone death, unusual thigh fractures and severe bone, joint or muscle pain. It is not used with esophagus problems that slow emptying, in people who cannot stay upright for 60 minutes, or with low calcium. In a 2-year trial of 150 mg monthly, belly pain was 7.8% and high blood pressure 6.3%. Full numbers are on the ibandronate side effects, ibandronate dosing schedule and missed ibandronate dose pages, and ibandronate vs Fosamax compares it with alendronate.
The ibandronate label says peak levels come 0.5 to 2 hours (median 1 hour) after a tablet taken fasting. Taking it with a standard breakfast cut absorption by about 90%, but there was no meaningful loss when it was taken at least 60 minutes before a meal. The apparent terminal half-life of the 150 mg tablet was 37 to 157 hours and depends on the dose and how sensitive the test is.
Numbers shown are taken from the source above. Half-life varies from person to person.
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