Empagliflozin (Jardiance): Half-Life and Label | Dose Track
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Empagliflozin: half-life, strengths and approval status

Tablet strengths · Approval status · Half-life ~12.4 hours

Short answer: Empagliflozin has a half-life of about 12.4 hours. Levels peak about 1.5 hours after a dose. People vary, so treat these as estimates.

What is empagliflozin?

Empagliflozin is an SGLT2 inhibitor: it makes the kidneys pass more sugar into the urine. It is sold as Jardiance, a once-daily tablet approved for type 2 diabetes, heart failure and chronic kidney disease.

Also known as: Jardiance.

Tablet strengths

Jardiance comes as 10 mg and 25 mg tablets.

Approval status and how it is used

The FDA Jardiance label approves it to lower the risk of heart-related death and hospital stays in adults with heart failure; to slow kidney decline in adults with chronic kidney disease; to lower the risk of heart-related death in adults with type 2 diabetes and heart disease; and, with diet and exercise, to improve blood sugar in adults and children 10 and older with type 2 diabetes. The label dose is 10 mg once a day in the morning, with or without food; for blood sugar it may be raised to 25 mg. It is not for blood sugar control in type 1 diabetes, or for blood sugar when eGFR is below 30.

Its first listed serious risk is ketoacidosis, which can happen with near-normal blood sugar. The label says to stop it at least 3 days before surgery or long fasting if possible; low food intake and ketogenic diets are listed among the triggers. It can also cause dehydration and low blood pressure, genital yeast infections and urinary infections. See the Jardiance side effects and missed dose pages.

Empagliflozin half-life and time to peak

  • Half-lifeabout 12.4 hours
  • Time to peak (Tmax)about 1.5 hours

The FDA Jardiance label gives an apparent terminal half-life of about 12.4 hours and peak levels 1.5 hours after a dose. A high-fat meal lowered the peak by about 37% and total exposure by about 16%, which the label does not consider clinically relevant.

Numbers shown are taken from the source above. Half-life varies from person to person.

How to track empagliflozin in Dose Track

  1. Add empagliflozin as a custom compound. Start typing its name and Dose Track fills in the details from its research library for you to check, and it sits next to everything else you take.
  2. Log each tablet when you take it, including split or fractional tablets, so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

DapagliflozinFarxiga · half-life about 12.9 hours CanagliflozinInvokana · half-life about 10.6 to 13.1 hours MetforminGlucophage · half-life about 6.2 hours SemaglutideOzempic, Wegovy · half-life about 7 days

Frequently asked questions

What is the half-life of empagliflozin?+
The FDA Jardiance label gives an apparent terminal half-life of about 12.4 hours and peak levels 1.5 hours after a dose. A high-fat meal lowered the peak by about 37% and total exposure by about 16%, which the label does not consider clinically relevant.
Should empagliflozin be stopped before surgery?+
The FDA Jardiance label says to withhold it for at least 3 days, if possible, before surgery or procedures with long fasting, because of the risk of ketoacidosis, and to restart once the person is stable and eating again.
Is Jardiance a GLP-1?+
No. Jardiance (empagliflozin) is an SGLT2 inhibitor that works in the kidneys. GLP-1 drugs such as semaglutide act on the GLP-1 hormone receptor. Some people take both.
Can I track empagliflozin in Dose Track?+
Yes. Empagliflozin is in Dose Track's research library, so when you add it as a custom compound its details are filled in for you to check. You can then log each tablet next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Jardiance (empagliflozin) prescribing information, sections 1, 2, 3, 5 and 12.3. DailyMed, February 2026.

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