Diethylpropion (also called amfepramone) is a stimulant appetite suppressant related to amphetamine, used for a few weeks alongside a calorie-restricted diet. It was first sold as Tenuate; this page uses a current label for generic 25 mg tablets.
Also known as: Tenuate, amfepramone, diethylpropion hydrochloride.
The label read here is for diethylpropion hydrochloride 25 mg immediate-release tablets.
The label approves diethylpropion as a short-term (a few weeks) add-on to a calorie-restricted weight-loss plan for obesity in people with a starting BMI of 30 or more who have not responded to diet and exercise alone. Label dosing: one 25 mg tablet three times a day, one hour before meals, plus one in midevening if desired for night hunger. It is continued only if weight loss is satisfactory in the first 4 weeks; if tolerance develops, the dose is not raised and the drug is stopped. The label says the tablets are Schedule IV controlled substances. It gives no missed-dose instruction.
The label has no boxed warning. It is not used with pulmonary hypertension, advanced hardening of the arteries, an overactive thyroid, glaucoma or severe high blood pressure, in agitated states or with a history of drug abuse, with another appetite suppressant, or within 14 days of an MAO inhibitor. Rare, often fatal pulmonary hypertension and heart valve disease have been reported with appetite suppressants, including with fenfluramine or dexfenfluramine; the label says heart valve disease has been reported very rarely with diethylpropion alone. Dependence and, rarely, psychosis have been reported. Side effects, listed without percentages, include fast or irregular heartbeat, raised blood pressure, restlessness, insomnia, dry mouth and constipation. See diethylpropion side effects, diethylpropion dosing schedule and diethylpropion vs phentermine.
The diethylpropion label we read gives no half-life or time to peak, so we do not list one. Its clinical pharmacology section describes it as a stimulant with actions similar to the amphetamines, including raised blood pressure, and says tolerance develops with drugs of this class.
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