Short answer: Cabergoline has a half-life of 63 to 69 hours (about 2.6 to 2.9 days). Levels peak 2 to 3 hours after a dose. People vary, so treat these as estimates.
Cabergoline is a dopamine agonist derived from ergot. It lowers prolactin, the pituitary hormone that drives milk production. It is sold as generic tablets; FDA lists the original brand, Dostinex, as discontinued.
Also known as: Dostinex.
Generic cabergoline comes as 0.5 mg scored tablets, the only strength on the FDA label.
The FDA label approves cabergoline for adults with hyperprolactinemic disorders (too much prolactin), either with no known cause or from a pituitary adenoma. The label dose starts at 0.25 mg twice a week, raised by 0.25 mg twice a week no more often than every 4 weeks until prolactin is normal, up to 1 mg twice a week. It can be taken with or without food. Any other use is off-label.
Before starting, the label calls for a heart evaluation including an echocardiogram, and cabergoline is not used if heart valve disease is found. During treatment the label recommends an echocardiogram every 6 to 12 months, because cases of heart valve disease and of fibrosis (scarring) around the heart, lungs and abdomen have been reported. Most valve cases came at doses above 2 mg a day for Parkinson's disease, an unapproved use, but some came at the lower doses used for high prolactin. The label also warns about new urges to gamble, spend or eat, and says not to use it to stop breast milk after birth.
The FDA cabergoline label gives an elimination half-life of 63 to 69 hours, estimated from urine data in 12 healthy people, and peak levels 2 to 3 hours after single doses of 0.5 to 1.5 mg. A high-fat meal did not change its pharmacokinetics.
Numbers shown are taken from the source above. Half-life varies from person to person.
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