5-Amino-1MQ: What It Is, Mouse Studies & Status
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5-Amino-1MQ: what it is, mouse studies and status

Amounts studied · Approval status · Half-life notes

What is 5-Amino-1MQ?

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule that blocks nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat-cell metabolism. It is not a peptide. It has been studied only in cells and mice and is not approved for human use.

Also known as: 5-amino-1-methylquinolinium, NNMT inhibitor.

Amounts studied

For 5-amino-1MQ, there is no approved product and no published human study, so there are no label strengths or studied human amounts.

Approval status and how it is used

5-Amino-1MQ is not FDA approved, and we could not find any published study that gave it to people.

In a 2018 study (Neelakantan), a potent methylquinolinium NNMT inhibitor, the chemical family 5-amino-1MQ belongs to, lowered body weight, white fat mass and plasma cholesterol in mice on a high-fat diet without changing how much they ate. In a 2024 study (Babula), 5-amino-1MQ given once a day for 28 days to obese mice limited weight and fat gain and improved glucose tolerance, insulin sensitivity and fatty liver. The 2024 paper states that its authors include the founder and current or former employees of Ridgeline Therapeutics. Mouse results often do not carry over to people.

5-Amino-1MQ half-life and time to peak

  • Half-lifeNot listed
  • Time to peak (Tmax)Not listed
  • Route in Dose TrackBy mouth (oral)

We could not find a published human half-life. The 2024 mouse study (Babula) measured blood levels after dosing into a vein, by mouth and under the skin in mice; animal numbers do not carry over to people, so we do not list one here.

How to track 5-Amino-1MQ in Dose Track

  1. Add 5-Amino-1MQ from the built-in list. It sits next to everything else you take, so a GLP-1, TRT and a few peptides all live in one log.
  2. Log each dose when you take it so your history shows exactly what you took and when.
  3. Set reminders on your own schedule, whether that is daily, weekly or every few days.
  4. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

How Dose Track handles peptides · Reconstitution calculator · Half-life calculator

SLU-PP-332 MOTS-c Oral NAD+ Precursors (NR and NMN)nicotinamide riboside, NR

Frequently asked questions

What is the half-life of 5-Amino-1MQ?+
We could not find a published human half-life. The 2024 mouse study (Babula) measured blood levels after dosing into a vein, by mouth and under the skin in mice; animal numbers do not carry over to people, so we do not list one here.
Has 5-amino-1MQ been tested in people?+
Not in any published study we could find. The research is in cells and mice (Neelakantan 2018; Babula 2024).
Can I track 5-Amino-1MQ in Dose Track?+
Yes. 5-Amino-1MQ is built into Dose Track. You can log each dose next to your other compounds, set reminders on your own schedule, and see your history next to your lab results. Your log is stored on your phone and no account is needed. Data only leaves it for features you choose, like AI answers and lab reading.

Sources

  1. Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.
  2. Babula JJ, et al. Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction. Diabetes Obes Metab. 2024.

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