Short answer: Neither has strong evidence. NIH says green tea preparations gave about 0.95 kg more loss than placebo, with no significant difference in trials outside Japan.1 Green coffee extract showed 2.47 kg in 3 trials, all of poor quality, and another trial was retracted.21 Green tea extract pills are linked to rare liver injury.3
| Green tea extract | Green coffee bean extract | |
|---|---|---|
| Main compounds | Catechins (mainly EGCG) and caffeine1 | Chlorogenic acid; also caffeine unless decaffeinated1 |
| Weight result | 0.95 kg more than placebo (14 trials); not significant outside Japan1 | 2.47 kg more than placebo (3 trials, all high risk of bias)2 |
| Trial quality (NIH) | Several trials of good quality1 | Few trials, all of poor quality; one retracted after FTC criticism1 |
| Liver | At least 50 case reports since 2006; mostly extract pills13 | Not flagged in the sources checked |
| Other side effects | Nausea, constipation, stomach discomfort, higher blood pressure3 | Headaches and urinary tract infections reported1 |
| Interactions | Nadolol, atorvastatin, raloxifene3 | Caffeine effects add up with other stimulants1 |
Green tea: NIH describes a Cochrane review of 14 trials lasting 12 to 13 weeks (141 to 1,207 mg catechins a day). Weight fell 0.95 kg more than placebo, but not significantly in the 6 trials outside Japan, and NIH concludes any effect is small and not likely to matter clinically.1
Green coffee: a 2011 meta-analysis of 3 trials found 2.47 kg more loss than placebo, but all trials had a high risk of bias.2 NIH notes another small trial reporting large losses was strongly criticized by the FTC, and two of its three authors retracted it.1
These are study protocols, not personalized advice; confirm any dosing with your prescriber.
NCCIH says liver injury, though uncommon, has been reported mainly with green tea extract tablets and capsules, and people with a specific immune gene variant (5% to 15% of Americans) appear more susceptible.3 NIH describes a 12-month trial in which extract with 843 mg of EGCG a day raised liver enzymes, and notes the US Pharmacopeia advises taking extracts with food.1
Both can contain caffeine. More detail: Xenical vs Wegovy: what do the labels show?, and the Green Tea Extract (EGCG) and Green Coffee Bean Extract guides.