Short answer: Ashwagandha is mostly studied for stress, anxiety and sleep; tongkat ali mostly for testosterone.12 Each has small trials touching the other's claim: ashwagandha raised salivary testosterone 14.7% more than placebo in one 8-week trial, and tongkat ali lowered salivary cortisol in a 4-week trial.34 No study compares them, and neither is FDA approved.5
| Ashwagandha | Tongkat ali | |
|---|---|---|
| Plant | Withania somnifera, an Ayurvedic shrub; most products use root extract1 | Eurycoma longifolia; studied as root extracts2 |
| Main studied use | Stress, anxiety and sleep1 | Testosterone in men2 |
| Testosterone data | One 8-week crossover trial in 57 overweight men aged 40 to 70: salivary testosterone up 14.7% more than placebo3 | Meta-analysis of 5 randomized trials: higher total testosterone, including in men with low testosterone2 |
| Stress-hormone data | NIH: may lower stress, anxiety and cortisol1 | 4-week trial in 63 stressed adults: salivary cortisol −16%4 |
| Safety summary | Seems well tolerated up to about 3 months; long-term safety unknown; liver injury reports; may affect thyroid1 | Little safety data in the sources checked here |
| FDA approval | Supplements are not approved by FDA before sale5 | Same5 |
NIH says research suggests ashwagandha extracts may lower stress, anxiety and cortisol and may help sleep, but studies used different preparations and doses, which makes recommendations hard.1
On hormones, one 16-week crossover trial gave overweight men aged 40 to 70 an ashwagandha extract or placebo for 8 weeks each. Salivary testosterone rose 14.7% more and DHEA-S 18% more on ashwagandha, but fatigue, vigor and sexual well-being did not differ from placebo.3
A 2022 systematic review included 9 studies and pooled 5 randomized trials. Total testosterone was higher with tongkat ali in both healthy men and men with low testosterone; the authors said more research is needed before clinical use.2
In a 4-week trial of 63 moderately stressed adults, a root extract lowered salivary cortisol by 16% and raised salivary testosterone by 37% compared with placebo, along with lower tension and anger scores.4
For ashwagandha, NIH lists mild side effects (loose stools, nausea, drowsiness), rare reports of liver injury, possible effects on thyroid function, and possible drug interactions. Some experts advise against it in pregnancy and in men with hormone-sensitive prostate cancer.1 For tongkat ali, the sources we checked give little safety data. If you are on TRT or thyroid medicine, ask your prescriber before adding either. These are study protocols, not personalized advice; confirm any dosing with your prescriber.
More detail: the Ashwagandha and Tongkat Ali guides.