Short answer: Section 17 of the Kazano label says that if a dose is missed, the next dose is not doubled. The Medication Guide says take a missed dose as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and take the next one at your regular time.
| Situation | What the label says |
|---|---|
| Schedule | Twice daily with food, raised gradually; tablets not split; up to 25 mg alogliptin and 2,000 mg metformin a day (2.1) |
| Missed a dose | Take it as soon as you remember (Medication Guide) |
| Time for the next dose | Skip the missed dose; take the next at your regular time (Medication Guide) |
| Doubling up | Do not double the next dose (17); do not take 2 doses at the same time (Medication Guide) |
Section 2 has no missed-dose rule. Section 17: "Instruct patients to take KAZANO only as prescribed twice daily and that it should be taken with food. Instruct patients if a dose is missed, not to double their next dose."
The Medication Guide says: "If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose, and take the next dose at your regular time. Do not take 2 doses of KAZANO at the same time."
The missed-dose wording does not say. Section 2.1 says Kazano is taken twice daily with food, with the dose raised gradually to reduce stomach side effects from metformin.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.