Short answer: The Duetact Medication Guide says: if you miss a dose, take your next dose as prescribed unless your doctor tells you differently, and do not take two doses at one time the next day. The prescribing information has no missed-dose rule. Duetact is one tablet once daily with the first main meal.
| Situation | What the label says |
|---|---|
| Schedule | 30 mg/2 mg or 30 mg/4 mg once daily with the first main meal; up to 45 mg pioglitazone and 8 mg glimepiride a day (2.1) |
| Missed a dose | Take the next dose as prescribed unless your doctor says otherwise (Medication Guide) |
| Doubling up | Do not take two doses at one time the next day (Medication Guide) |
| Prescribing information | No missed-dose rule |
The prescribing information has no missed-dose rule. The Medication Guide says: "If you miss a dose of DUETACT, take your next dose as prescribed unless your doctor tells you differently. Do not take two doses at one time the next day" (printed without a closing period).
The label does not say. Section 2.1 says Duetact is taken once daily with the first main meal. Section 5.2 says glimepiride, like all sulfonylureas, can cause severe low blood sugar. Whether to take a late dose is a question for your prescriber or pharmacist.
This page summarizes FDA labeling. It is not personalized medical advice; confirm what to do with your prescriber or pharmacist.