Osteoporosis: Definition and the Labels That Treat It
[Glossary · How doses act in the body]

Osteoporosis

Also called postmenopausal osteoporosis, bone loss, osteopenia · Reviewed

Definition: Osteoporosis is a bone disease in which bone mineral density and bone mass drop, or bone structure and strength change, so bones break more easily. NIAMS calls it a silent disease because there are usually no symptoms until a bone breaks. Osteopenia, the NCI says, is a milder form of low bone mass.

How it is found

NIAMS says fractures happen most often in the hip, spine and wrist, and that osteoporosis is the major cause of fractures in postmenopausal women and older men. It is usually found by screening with a bone mineral density test. The most common test is DXA, and DXA at the hip and spine is generally considered the most reliable way to diagnose it and predict fracture risk.

Medicines with it on the label

  • Bisphosphonates: Fosamax is approved to treat and prevent it in postmenopausal women and to increase bone mass in men; Atelvia treats it in postmenopausal women.
  • SERM: Evista treats and prevents it in postmenopausal women.
  • Estrogen: Climara, Vivelle-Dot and Premarin are approved to prevent postmenopausal osteoporosis, but their labels say non-estrogen medicines are considered first when bone is the only reason.

Bisphosphonate labels warn about jaw bone death and unusual thigh fractures, and say people at low fracture risk may be considered for stopping after 3 to 5 years.

Why it matters for your log

Many bone medicines are weekly or monthly, with strict rules about food and water. Logging each dose and the date of each scan shows how long you have been on treatment, which the labels use when discussing a pause.

Read more on Dose Track: Osteoporosis medicines for men · How long can you take bisphosphonates · Calcium and vitamin D with bone medicines · Fosamax side effects

General education drawn from labels and published studies, not personal medical advice. Your prescriber, pharmacist and the label that came with your product are the final word.

Frequently asked questions

What is the difference between osteopenia and osteoporosis?+
The NCI describes osteopenia as lower than normal bone mass or density, a less severe form of bone loss than osteoporosis.
How is osteoporosis diagnosed?+
NIAMS says it is usually found by screening with a bone mineral density test, most often a DXA scan of the hip and spine.