Uridine is sold as a supplement, usually as uridine monophosphate (UMP). A related compound, uridine triacetate, is an FDA-approved prescription drug that delivers uridine to the body for two rare uses.
Also known as: uridine monophosphate, UMP, 5'-UMP, uridine triacetate.
For supplements, the one trial we found gave UMP for 2 weeks; its abstract does not state the amount (Inoue 2024). For the prescription drug, the Xuriden label starts at 60 mg/kg once a day for hereditary orotic aciduria. Neither is a recommendation for supplement use.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling. It is not the same product as the prescription drugs below.
Prescription uridine triacetate: FDA-approved as Xuriden for hereditary orotic aciduria, a rare inherited disorder, and as Vistogard for emergency treatment after an overdose of the cancer drugs fluorouracil or capecitabine, or early severe toxicity from them. The labels say uridine triacetate delivers 4 to 6 times more uridine into the blood than the same molar amount of uridine itself.
What studies show for supplements: in a placebo-controlled trial in 21 healthy men who stopped 6 weeks of arm training, UMP limited the loss of muscle thickness at one of three measurement sites after 1 week, but not at the other two (Inoue 2024). The trial was funded by YAMASA Corporation, which supplied the UMP. We found little other evidence for uridine supplements on their own.
Safety: the sources here do not describe side effects or drug interactions for uridine supplements.
We do not list a figure for uridine supplements. For the prescription drug uridine triacetate, the label says blood uridine peaks within 2 to 3 hours and has a half-life of about 2 to 2.5 hours; that applies to the drug, not to UMP supplements.
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