Serrapeptase (serratiopeptidase) is a protein-digesting enzyme. It is prescribed in some countries after surgery and in dentistry, orthopedics and ear, nose and throat care for swelling and pain, and it is promoted as a supplement for heart health.
Also known as: serratiopeptidase, serratio peptidase, serrapeptidase.
The 2013 systematic review found that some studies did not even state the dose or treatment length (Bhagat 2013). We do not list an amount.
It is sold in the US as a dietary supplement. Under the 1994 dietary supplement law (DSHEA), FDA does not approve dietary supplements before they are marketed, and the maker, not FDA, is responsible for safety and labeling.
What studies show: a 2013 systematic review of 24 studies found that the evidence for serrapeptase as an anti-inflammatory and pain reliever comes from poorly designed studies, mostly small, and is not enough to support its use for pain or as a health supplement (Bhagat 2013). A 2018 meta-analysis of 5 studies after wisdom tooth removal found that serrapeptase improved jaw opening more than corticosteroids but did not differ from them for facial swelling; there were too few studies to judge other outcomes (Sivaramakrishnan 2018).
Safety: the 2013 review found that the studies lacked safety and tolerability data and that long-term safety data are missing (Bhagat 2013). The sources here do not describe drug interactions.
We could not find a single published half-life or time to peak for serrapeptase that applies to a supplement dose, so we do not list one.
How Dose Track handles peptides · Reconstitution calculator · Half-life calculator